Itm2c Gene Summary [Rat]
Predicted to enable ATP binding activity and amyloid-beta binding activity. Predicted to be involved in several processes, including negative regulation of amyloid precursor protein biosynthetic process; negative regulation of neuron projection development; and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in lysosome and perinuclear region of cytoplasm. Predicted to be active in Golgi apparatus and plasma membrane. Orthologous to human ITM2C (integral membrane protein 2C). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itm2c |
| Official Name | integral membrane protein 2C [Source:RGD Symbol;Acc:1309503] |
| Ensembl ID | ENSRNOG00000017359 |
| Bio databases IDs | |
| Aliases | integral membrane protein 2C |
| Synonyms | 3110038L02Rik, BRI3, BRICD2C, Cerebral protein-14, E25, E25C, hucep-14, integral membrane protein 2C, Integral membrane protein 3, ITM3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itm2c often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ATP binding
- protein binding
- BRICHOS domain
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- celiac disease
- colorectal adenoma
- colorectal adenoma formation
- androgenic alopecia
- angioimmunoblastic T-cell lymphoma
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- colorectal cancer
regulates
role in cell
- production in
- development
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cellular membrane
- Plasma Membrane
- lysosome
- Golgi Apparatus
- synaptic vesicles
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itm2c gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of neuron projection development
- neuron differentiation
- positive regulation of extrinsic apoptotic signaling pathway
- negative regulation of amyloid precursor protein biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- Golgi apparatus
- lysosomal membrane
- plasma membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- beta-amyloid binding