Ciita Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to electrical stimulus; cellular response to exogenous dsRNA; and regulation of transcription by RNA polymerase II. Located in cell surface. Used to study periapical periodontitis. Human ortholog(s) of this gene implicated in Addison's disease; MHC class II deficiency; autoimmune disease (multiple); and myocardial infarction. Orthologous to human CIITA (class II major histocompatibility complex transactivator). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ciita |
| Official Name | class II, major histocompatibility complex, transactivator [Source:RGD Symbol;Acc:619813] |
| Ensembl ID | ENSRNOG00000002659 |
| Bio databases IDs | |
| Aliases | class II, major histocompatibility complex, transactivator |
| Synonyms | C2TA, C2TA10, CIITAIV, Ciita Type 4, class II major histocompatibility complex transactivator, class II, major histocompatibility complex, transactivator, class II transactivator, EG669998, Gm9475, LOC100503847, MHC2D1, MHC2TA, NLRA |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ciita often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NLRC4 helical domain HD2
- transcription regulator
- transcription co-activator
- GTP-binding protein motif, guanosine specific
- transcription co-repressor
- Pst domain
- Leucine rich repeat
- transcription activation domain
- transcription factor binding
- Leucine Rich repeats (2 copies)
- NACHT domain
- leucine-rich repeat
- GTP binding motif, P-loop
- P-loop containing Nucleoside Triphosphate Hydrolases
- GTP binding domain
- magnesium binding domain
- leucine rich domain
- protein phosphatase 1 regulatory subunit 42
- nuclear export signal
- nucleic acid binding
- GTP binding motif, magnesium-coordinating
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- acidic domain
- p300/cbp binding domain
- binding protein
- STP box
- double-stranded DNA binding
- Leucine rich repeat, ribonuclease inhibitor type
- CBP binding domain
Pathways
Biological processes and signaling networks where the Ciita gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- squamous cell cancer
- epithelial cancer
- asthma
- acne
- infection
- bare lymphocyte syndrome type II
- Huntington disease
- bare lymphocyte syndrome type II complementation group A
- non-Hodgkin lymphoma
role in cell
- expression in
- proliferation
- differentiation
- formation
- activation in
- inhibition in
- number
- quantity
- development
- cellular infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cell surface
- cytosol
- nucleoplasm
- PML nuclear bodies
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ciita gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of collagen biosynthetic process
- immune response
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- negative regulation of viral entry into host cell
- response to interferon-gamma
- response to antibiotic
- positive regulation of MHC class I biosynthetic process
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of MHC class II biosynthetic process
Cellular Component
Where in the cell the gene product is active
- PML body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- ATP binding
- DNA binding
- transferase activity, transferring acyl groups
- protein binding
- transcription coactivator activity
- transcription regulatory region sequence-specific DNA binding
- protein serine/threonine kinase activity