Eml1 Gene Summary [Rat]
Predicted to enable microtubule binding activity. Predicted to be involved in brain development; mitotic spindle organization; and neuroblast proliferation. Predicted to act upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and microtubule cytoskeleton. Predicted to colocalize with mitotic spindle. Used to study epilepsy and subcortical band heterotopia. Human ortholog(s) of this gene implicated in skin melanoma and subcortical band heterotopia. Orthologous to human EML1 (EMAP like 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eml1 |
| Official Name | EMAP like 1 [Source:RGD Symbol;Acc:1306374] |
| Ensembl ID | ENSRNOG00000043143 |
| Bio databases IDs | |
| Aliases | EMAP like 1 |
| Synonyms | 1110008N23Rik, A930030P13Rik, AI847476, AI853955, BH, echinoderm microtubule associated protein like 1, ELP79, EMAP, EMAP-1, EMAPL, EMAP like 1, heco |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Eml1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- microtubule binding
- WD40 repeats
- tubulin binding
- TD_EMAP-like
- HELP motif
- WD domain, G-beta repeat
- WD40
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hydrocephalus
- major depression
- band heterotopia of brain
- Huntington disease
- band heterotopia
- coronary artery disease
- polycystic ovary syndrome
role in cell
- differentiation
- proliferation
- size
- organization
- S phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubule cytoskeleton
- microtubules
- cytosol
- spindle pole
- central spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Eml1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuroblast proliferation
- mitotic spindle organization
- brain development
- microtubule cytoskeleton organization
- hemopoietic progenitor cell differentiation
Cellular Component
Where in the cell the gene product is active
- microtubule cytoskeleton
- perinuclear region of cytoplasm
- mitotic spindle
- cytosol
- microtubule associated complex
- microtubule
Molecular Function
What the gene product does at the molecular level
- tubulin binding
- protein binding
- calcium ion binding
- microtubule binding