Fbxo28 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in protein polyubiquitination. Predicted to be located in kinetochore. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 100. Orthologous to human FBXO28 (F-box protein 28). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo28 |
| Official Name | F-box protein 28 [Source:RGD Symbol;Acc:1304584] |
| Ensembl ID | ENSRNOG00000000066 |
| Bio databases IDs | |
| Aliases | F-box protein 28 |
| Synonyms | 4833428J17Rik, 5730505P19Rik, CENP-30, D1Ertd578e, DEE100, F-box protein 28, Fbx28, KIAA0483, LOC100361530, mKIAA0483 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fbxo28 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain superfamily
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- liver cancer
- major depression
- developmental and epileptic encephalopathy type 100
- organismal death
- hereditary disorder
- pancreatic cancer
- metastasis
- hepatocellular carcinoma
role in cell
- expression in
- migration
- invasion by
- proliferation
- ubiquitination in
- K48 polyubiquitination in
- polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fbxo28 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein polyubiquitination
Cellular Component
Where in the cell the gene product is active
- kinetochore
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding