Kit Gene Summary [Rat]
Enables protein tyrosine kinase activity. Involved in several processes, including positive regulation of Notch signaling pathway; positive regulation of gastro-intestinal system smooth muscle contraction; and protein phosphorylation. Located in acrosomal vesicle; cytoplasmic side of plasma membrane; and external side of plasma membrane. Used to study aplastic anemia and male infertility. Biomarker of acute pancreatitis; gastroschisis; and ileus. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal stromal tumor; germ cell cancer (multiple); mastocytosis; piebaldism; and renal cell carcinoma. Orthologous to human KIT (KIT proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kit |
| Official Name | KIT proto-oncogene receptor tyrosine kinase [Source:RGD Symbol;Acc:620568] |
| Ensembl ID | ENSRNOG00000002227 |
| Bio databases IDs | |
| Aliases | KIT proto-oncogene receptor tyrosine kinase |
| Synonyms | Ack2, Bs, CD117, c-KIT, C-Kit1, c-Kit Gnnk+, Fdc, Gsfsco1, Gsfsco5, Gsfsow3, KIT proto-oncogene receptor tyrosine kinase, KIT proto-oncogene, receptor tyrosine kinase, MASTC, PBT, SCFR, SCO1, SCO5, SCR, SOW3, Ssm, white-spotted |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Kit often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PI3K binding domain
- phosphotransferase domain
- cytokine binding
- protein-tyrosine kinase
- Protein kinase domain
- kinase insertion domain
- activation loop
- ATP-binding pocket
- cytoplasmic domain
- ligand-binding domain
- stem cell factor receptor
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- tail domain
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- dimerization domain
- protease binding
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- SH2-domain binding
- immunoglobulin domain
- ectodomain
- Immunoglobulin I-set domain
- autophosphorylation site
- protein binding
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- transmembrane receptor protein tyrosine kinase
- PLC gamma1 protein binding domain
- transmembrane domain
- tyrosine kinase domain
- protein homodimerization
Pathways
Biological processes and signaling networks where the Kit gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial neoplasia
- epithelial cancer
- cancer
- neoplasia
- rheumatoid arthritis
- systemic lupus erythematosus
- schizophrenia
- COVID-19
- hyperplasia
- airway hyperresponsiveness
role in cell
- differentiation
- binding in
- number
- expression in
- quantity
- phosphorylation in
- proliferation
- apoptosis
- activation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- fibrillar center
- Cytoplasm
- cell surface
- Extracellular Space
- membrane surface
- cellular membrane
- Nucleus
- vesicles
- intercellular junctions
- cell-cell contacts
- cytoplasmic face of plasma membrane
- plasma membrane extracellular face
- sperm tail
- acrosome
- sperm head
- cytoplasmic droplets
- membrane rafts
- membrane processes
- perikaryon
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Kit gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- embryonic hemopoiesis
- protein autophosphorylation
- visual learning
- negative regulation of developmental process
- negative regulation of programmed cell death
- positive regulation of tyrosine phosphorylation of STAT protein
- tongue development
- mast cell degranulation
- positive regulation of sequence-specific DNA binding transcription factor activity
- lymphoid progenitor cell differentiation
- hemopoietic progenitor cell differentiation
- glycosphingolipid metabolic process
- cell chemotaxis
- inflammatory response
- epithelial cell proliferation
- digestive tract development
- pigmentation
- myeloid progenitor cell differentiation
- detection of mechanical stimulus involved in sensory perception of sound
- Kit signaling pathway
- intracellular signal transduction
- positive regulation of mast cell cytokine production
- stem cell maintenance
- germ cell programmed cell death
- B cell differentiation
- positive regulation of pseudopodium assembly
- germ cell migration
- positive regulation of JAK-STAT cascade
- T cell differentiation
- erythrocyte differentiation
- immature B cell differentiation
- hematopoietic stem cell migration
- negative regulation of reproductive process
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- positive regulation of long-term neuronal synaptic plasticity
- positive regulation of MAP kinase activity
- regulation of cell shape
- multicellular organismal development
- hemopoiesis
- positive regulation of Notch signaling pathway
- Fc receptor signaling pathway
- positive regulation of dendritic cell cytokine production
- stem cell differentiation
- mast cell proliferation
- cytokine-mediated signaling pathway
- somatic stem cell maintenance
- megakaryocyte development
- positive regulation of mast cell proliferation
- mast cell differentiation
- spermatid development
- signal transduction
- spermatogenesis
- response to cadmium ion
- erythropoietin-mediated signaling pathway
- positive regulation of MAPK cascade
- mast cell chemotaxis
- regulation of cell proliferation
- ovarian follicle development
- melanocyte differentiation
- lamellipodium assembly
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cell-cell junction
- acrosomal vesicle
- external side of plasma membrane
- receptor complex
- fibrillar center
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- growth factor binding
- protein tyrosine kinase activity
- protein binding
- protein homodimerization activity
- metal ion binding
- transmembrane receptor protein tyrosine kinase activity
- stem cell factor receptor activity
- protease binding
- SH2 domain binding
- cytokine binding