Cdh3 Gene Summary [Rat]
Predicted to enable beta-catenin binding activity and cadherin binding activity. Involved in response to xenobiotic stimulus. Predicted to be located in cell junction and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in adherens junction and cytoplasm. Human ortholog(s) of this gene implicated in congenital hypotrichosis with juvenile macular dystrophy and ectodermal dysplasia, ectrodactyly, and macular dystrophy syndrome. Orthologous to human CDH3 (cadherin 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdh3 |
| Official Name | cadherin 3 [Source:RGD Symbol;Acc:621089] |
| Ensembl ID | ENSRNOG00000020129 |
| Bio databases IDs | |
| Aliases | cadherin 3 |
| Synonyms | cadherin 3, Cadp, CDHP, HJMD, PCAD, P-cadherin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdh3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Cadherin, Y-type LIR-motif
- ectodomain
- Cadherin repeat-like domain
- membrane-proximal domain
- extracellular cadherin structural domain
Pathways
Biological processes and signaling networks where the Cdh3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- cutaneous melanoma
- neoplasia
- retinitis pigmentosa
- renal cell carcinoma
- renal cell cancer
- congenital hypotrichosis with juvenile macular dystrophy
- organismal death
- breast cancer
- prostate cancer
role in cell
- expression in
- apoptosis
- proliferation
- survival
- cellular infiltration by
- phosphorylation in
- invasion by
- activation in
- transformation
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- cell surface
- cell borders
- cellular membrane
- cell-cell contacts
- basal cell surfaces
- apical membrane
- anchoring junction
- cell membrane leading edge
- cell-cell adherens junctions
- plasma
- podocyte slit diaphragm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdh3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-dependent cell-cell adhesion
- cell-cell junction assembly
- adherens junction organization
- multicellular organismal development
- cell morphogenesis
- positive regulation of canonical Wnt receptor signaling pathway
- cell adhesion
- response to xenobiotic stimulus
- hair cycle process
- homophilic cell adhesion
- visual perception
- positive regulation of insulin-like growth factor receptor signaling pathway
- negative regulation of catagen
- positive regulation of melanin biosynthetic process
- retina homeostasis
- positive regulation of keratinocyte proliferation
- cell-cell adhesion mediated by cadherin
- positive regulation of gene expression
- positive regulation of monophenol monooxygenase activity
- keratinization
- cell migration
- negative regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoplasm
- cell junction
- catenin complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- cadherin binding
- beta-catenin binding