Dlx1 Gene Summary [Rat]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Predicted to be involved in several processes, including negative regulation of cellular response to growth factor stimulus; regulation of neuron differentiation; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including forebrain development; negative regulation of Notch signaling pathway; and negative regulation of oligodendrocyte differentiation. Predicted to be located in cytosol and nucleoplasm. Orthologous to human DLX1 (distal-less homeobox 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dlx1 |
| Official Name | distal-less homeobox 1 [Source:RGD Symbol;Acc:1309593] |
| Ensembl ID | ENSRNOG00000001520 |
| Bio databases IDs | |
| Aliases | distal-less homeobox 1 |
| Synonyms | DII B, distal-less homeobox 1, Dlx |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Dlx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- homeodomain
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- renal clear cell adenocarcinoma
- psychosis
- renal clear cell cancer
- prostate cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
role in cell
- migration
- growth
- proliferation
- activation in
- apoptosis
- expression in
- number
- quantity
- development
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Dlx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryo development
- oligodendrocyte differentiation
- forebrain neuron differentiation
- subpallium development
- odontogenesis of dentin-containing tooth
- positive regulation of cell differentiation
- hippocampus development
- negative regulation of photoreceptor cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of Notch signaling pathway
- embryonic skeletal system development
- cerebral cortex GABAergic interneuron fate commitment
- negative regulation of oligodendrocyte differentiation
- proximal/distal pattern formation
- negative regulation of neuron apoptotic process
- negative regulation of BMP signaling pathway
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to transforming growth factor beta stimulus
- Notch signaling pathway
- cellular response to BMP stimulus
- cell differentiation
- neuron apoptotic process
- neuroblast differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- intracellular membrane-bounded organelle
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- chromatin binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity