Flot2 Gene Summary [Rat]
Enables ionotropic glutamate receptor binding activity and protease binding activity. Predicted to be involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of canonical NF-kappaB signal transduction; and protein localization to cell periphery. Located in caveola. Part of flotillin complex. Is active in glutamatergic synapse and presynaptic active zone membrane. Orthologous to human FLOT2 (flotillin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flot2 |
| Official Name | flotillin 2 [Source:RGD Symbol;Acc:70993] |
| Ensembl ID | ENSRNOG00000009681 |
| Bio databases IDs | |
| Aliases | flotillin 2 |
| Synonyms | CAVATELLIN, ECS-1, EPIDERMAL SURFACE AG 1, ESA, ESA1, Flotillin-2, Flotillin2/esa, M17S1, reggie-2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Flot2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPFH_like
- cholesterol Recognition/interaction Amino acid Consensus domain
- protease binding
- prohibitin homologues
- protein binding
- SPFH domain / Band 7 family
- ionotropic glutamate receptor binding
Pathways
Biological processes and signaling networks where the Flot2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Parkinson disease
- severe acute respiratory syndrome
- galactosylceramide beta-galactosidase deficiency
role in cell
- apoptosis
- expression in
- growth
- phosphorylation in
- activation in
- internalization in
- abnormal morphology
- biosynthesis in
- degradation in
- dimerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- raft fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- cortical actin cytoskeleton
- cell surface
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- vesicles
- Mitochondria
- intercellular junctions
- cell-cell contacts
- caveolar membranes
- uropod
- presynaptic membrane
- caveolae
- basolateral membrane
- acrosome
- synapse
- late endosomes
- cytoplasmic vesicles
- endocytotic vesicle
- membrane rafts
- exosomes
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Flot2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of gene expression
- regulation of myoblast differentiation
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- epidermis development
- cell adhesion
- regulation of heterotypic cell-cell adhesion
- protein stabilization
- protein localization in plasma membrane
- regulation of toll-like receptor 3 signaling pathway
Cellular Component
Where in the cell the gene product is active
- acrosomal membrane
- plasma membrane
- cell-cell contact zone
- endocytic vesicle
- adherens junction
- caveola
- perinuclear region of cytoplasm
- endosome
- extracellular vesicular exosome
- uropod
- focal adhesion
- intracellular membrane-bounded organelle
- dendrite cytoplasm
- membrane
- cytoplasmic vesicle
- vesicle
- basolateral plasma membrane
- apical plasma membrane
- cortical actin cytoskeleton
- lamellipodium
- flotillin complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- protease binding