Tnfrsf1a Gene Summary [Rat]
Enables protease binding activity; tumor necrosis factor binding activity; and tumor necrosis factor receptor activity. Involved in several processes, including cellular response to estradiol stimulus; regulation of apoptotic process; and regulation of cytokine production. Located in axon; cell surface; and extracellular space. Part of protein-containing complex. Used to study brain ischemia; ischemia; middle cerebral artery infarction; myocardial infarction; and uveitis. Biomarker of several diseases, including root resorption; sciatic neuropathy; transient cerebral ischemia; type 2 diabetes mellitus; and ureteral obstruction. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; TNF receptor-associated periodic syndrome; acne; allergic bronchopulmonary aspergillosis; and autoimmune disease (multiple). Orthologous to human TNFRSF1A (TNF receptor superfamily member 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tnfrsf1a |
| Official Name | TNF receptor superfamily member 1A [Source:RGD Symbol;Acc:621237] |
| Ensembl ID | ENSRNOG00000031312 |
| Bio databases IDs | |
| Aliases | TNF receptor superfamily member 1A |
| Synonyms | CD120a, FPF, p55, p55-R, p55 TNF alpha receptor, p55 TNF α receptor, p60, TBP1, TNF-alphaR1, Tnf alpha receptor p60, TNFAR, TNF-R, TNF-R1, Tnfr-2, TNF-R55, TNFR60, TNF receptor 1, TNF receptor superfamily member 1A, TNF-R-I, TNFRp55, Tnf-α Receptor 2, Tnf α receptor p60, Tnf α Receptor Type1, Tnf-α receptor type I, tumor necrosis factor receptor superfamily, member 1a, tumour necrosis factor receptor 1, tumour necrosis factor receptor superfamily, member 1a |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Tnfrsf1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Death domain
- cytokine binding
- Acid sphingomyelinase (A-SMase) activation domain
- cytoplasmic domain
- ligand-binding domain
- intracellular domain
- membrane-proximal domain
- transmembrane receptor
- cysteine rich domain
- extracellular domain
- stem region
- signaling receptor activity
- protease binding
- ectodomain
- TNFR/NGFR cysteine-rich region
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- pre-ligand assembly domain
- FAN binding domain
- binding protein
- tumor necrosis factor receptor
- transmembrane domain
- Neutral sphingomyelinase (N-SMase) domain
- PXXP motif
- Death Domain Superfamily of protein-protein interaction domains
Pathways
Biological processes and signaling networks where the Tnfrsf1a gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Acute Phase Response Signaling
- Adipogenesis pathway
- Apoptosis Signaling
- Autophagy
- Ceramide Signaling
- Death Receptor Signaling
- Dendritic Cell Maturation
- Germ Cell-Sertoli Cell Junction Signaling
- IL-6 Signaling
- ILK Signaling
- Induction of Apoptosis by HIV1
- LPS/IL-1 Mediated Inhibition of RXR Function
- LXR/RXR Activation
- Myc Mediated Apoptosis Signaling
- NF-κB Signaling
- Osteoarthritis Pathway
- p38 MAPK Signaling
- PPAR Signaling
- Production of Nitric Oxide and Reactive Oxygen Species in Macrophages
- T Helper Cell Differentiation
- Tight Junction Signaling
- TNFR1 Signaling
- Type II Diabetes Mellitus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cirrhosis
- thrombosis
- pneumonia
- non-insulin-dependent diabetes mellitus
- insulin resistance
- diabetes mellitus
- inflammatory disorder
- glioblastoma
- early-onset preeclampsia
role in cell
- expression in
- proliferation
- cellular infiltration by
- apoptosis
- growth
- production in
- activation in
- migration
- cell death
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- raft fractions
- membrane fraction
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- apical compartment
- perinuclear region
- cellular membrane
- vesicles
- lysosome
- Golgi Apparatus
- Mitochondria
- cytosol
- lateral cell surfaces
- apical cell surfaces
- apical membrane
- caveolae
- Golgi membrane
- trans Golgi network
- perinuclear space
- neurites
- cytoplasmic vesicles
- membrane rafts
- perikaryon
- axons
- dendrites
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Tnfrsf1a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of cellular amide metabolic process
- negative regulation of inflammatory response
- positive regulation of inflammatory response
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- transcription from RNA polymerase II promoter
- prostaglandin metabolic process
- DNA damage response, signal transduction resulting in induction of apoptosis
- aortic valve development
- positive regulation of tyrosine phosphorylation of STAT protein
- induction of apoptosis via death domain receptors
- pulmonary valve development
- positive regulation of lipid metabolic process
- positive regulation of transcription from RNA polymerase II promoter
- defense response to bacterium
- negative regulation of extracellular matrix constituent secretion
- positive regulation of execution phase of apoptosis
- tumor necrosis factor-mediated signaling pathway
- cellular response to mechanical stimulus
- inflammatory response
- negative regulation of cardiac muscle hypertrophy
- cytokine-mediated signaling pathway
- regulation of tumor necrosis factor-mediated signaling pathway
- protein localization in plasma membrane
Cellular Component
Where in the cell the gene product is active
- extracellular space
- membrane raft
- membrane
- receptor complex
- Golgi membrane
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- tumor necrosis factor-activated receptor activity
- tumor necrosis factor binding