Cdc42 Gene Summary [Rat]
Enables GTP binding activity and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including actin filament branching; establishment of Golgi localization; and regulation of synapse organization. Located in Golgi membrane; plasma membrane; and secretory granule. Is active in Schaffer collateral - CA1 synapse. Biomarker of temporal lobe epilepsy. Human ortholog(s) of this gene implicated in fibrosarcoma. Orthologous to human CDC42 (cell division cycle 42). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc42 |
| Official Name | cell division cycle 42 [Source:RGD Symbol;Acc:71043] |
| Ensembl ID | ENSRNOG00000013536 |
| Bio databases IDs | |
| Aliases | cell division cycle 42 |
| Synonyms | Cdc42 homolog, CDC42Hs, cell division cycle 42, CELLULAR GROWTH REGULATING, G25K, LOC100503638, LOC108168959, LOC643751, TKS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cdc42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- effector loop
- Ras family
- enzyme
- identical protein binding
- effector domain
- Rho insert region
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- GTP-dependent protein binding
- protein kinase binding
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- ubiquitin protein ligase activity
- enzyme binding
- GTPase
- protein domain specific binding
- protein binding
- receptor binding
- prenylation site
- Ras subfamily of RAS small GTPases
- GTP binding
- beta strand or sheet
- ADP-ribosylation factor family
- CAAX box
- small GTP-binding protein domain
- GTPase domain
- Rab subfamily of small GTPases
- guanine nucleotide exchange factor domain
- Pak binding domain
Pathways
Biological processes and signaling networks where the Cdc42 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Clathrin-mediated Endocytosis Signaling
- CXCR4 Signaling
- Ephrin A Signaling
- Ephrin B Signaling
- Ephrin Receptor Signaling
- ErbB Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- Germ Cell-Sertoli Cell Junction Signaling
- Glioblastoma Multiforme Signaling
- Gα12/13 Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- LPS-stimulated MAPK Signaling
- Macropinocytosis Signaling
- Neurotrophin/TRK Signaling
- PAK Signaling
- Reelin Signaling in Neurons
- Renal Cell Carcinoma Signaling
- Semaphorin Signaling in Neurons
- Sertoli Cell-Sertoli Cell Junction Signaling
- TGF-β Signaling
- TNFR1 Signaling
- Virus Entry via Endocytic Pathways
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- neoplastic cell transformation
- COVID-19
- leukocytosis
- hereditary disorder
- leiomyomatosis
- non-insulin-dependent diabetes mellitus
- breast cancer
- Takenouchi-Kosaki syndrome
- lymphomagenesis
regulated by
- ethanol
- fluvastatin
- Ca2+
- lipopolysaccharide
- D-glucose
- fibroblasts
- TAFAZZIN
- indomethacin
- ketorolac
- mast cells
role in cell
- expression in
- transcription in
- differentiation
- invasion
- phosphorylation in
- activation in
- proliferation
- cell death
- formation
- redistribution in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- plasma membrane fraction
- myelin enriched fraction
- soluble fraction
- primary granule fractions
- membrane fraction
- apicolateral membrane
- glutaminergic synapse
- extracellular vesicles
- cytoplasmic ribonucleoprotein granule
- cilia
- perinuclear membrane
- cell periphery
- apical compartment
- perinuclear region
- postsynaptic region
- cellular membrane
- podosomes
- Nucleus
- vacuole
- Plasma Membrane
- centrosome
- Golgi Apparatus
- midbody
- actin bundles
- intercellular junctions
- cytoplasmic particles
- granules
- microtubule organizing centers
- cytosol
- endoplasmic reticulum membrane
- membrane ruffles
- Golgi membrane
- nuclear envelope
- dendritic spines
- growth cone
- neurites
- nerve ending
- synapse
- storage granules
- secretory granules
- cellular protrusions
- membrane processes
- filopodia
- cell membrane leading edge
- central spindle
- mitotic spindle
- perikaryon
- axons
- dendrites
- presynaptic terminals
- exosomes
- phagosomes
- lamellipodia
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cdc42 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- heart contraction
- actin filament branching
- nuclear migration
- positive regulation of filopodium assembly
- sprouting angiogenesis
- protein localization
- regulation of stress fiber assembly
- actin filament organization
- cardiac neural crest cell migration involved in outflow tract morphogenesis
- regulation of filopodium assembly
- organelle transport along microtubule
- positive regulation of cell growth
- phagocytosis, engulfment
- establishment of Golgi localization
- Cdc42 protein signal transduction
- macrophage differentiation
- positive regulation of lamellipodium assembly
- regulation of lamellipodium assembly
- positive regulation of pseudopodium assembly
- positive regulation of substrate adhesion-dependent cell spreading
- endocytosis
- dendritic spine morphogenesis
- regulation of actin cytoskeleton organization
- positive regulation of stress fiber assembly
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
- positive regulation of intracellular protein transport
- submandibular salivary gland formation
- adherens junction organization
- Golgi organization
- positive regulation of DNA replication
- positive regulation of neuron apoptotic process
- positive regulation of epithelial cell proliferation involved in lung morphogenesis
- integrin-mediated signaling pathway
- neuron fate determination
- establishment of epithelial cell apical/basal polarity
- negative regulation of protein complex assembly
- Wnt receptor signaling pathway, planar cell polarity pathway
- cell junction assembly
- regulation of attachment of spindle microtubules to kinetochore
- positive regulation of cytokinesis
- regulation of mitosis
- cardiac conduction system development
- establishment or maintenance of cell polarity
- embryonic heart tube development
- filopodium assembly
- substantia nigra development
- positive regulation of pinocytosis
- positive regulation of JNK cascade
- positive regulation of synapse structural plasticity
- cellular response to interferon-gamma
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- Golgi transport complex
- Golgi membrane
- neuronal cell body
- neuron projection
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- mitotic spindle
- focal adhesion
- apical part of cell
- dendritic spine
- cytosol
- leading edge membrane
- secretory granule
- phagocytic vesicle
- plasma membrane
- storage vacuole
- centrosome
- spindle midzone
- cell-cell junction
- cytoplasm
- membrane
- filopodium
- macromolecular complex
- midbody
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein kinase binding
- GBD domain binding
- identical protein binding
- protein binding
- GTPase activity
- small monomeric GTPase activity
- thioesterase binding
- mitogen-activated protein kinase kinase kinase binding
- apolipoprotein A-I receptor binding
- GTP-dependent protein binding