Vav1 Gene Summary [Rat]
Predicted to enable guanyl-nucleotide exchange factor activity; phosphorylation-dependent protein binding activity; and phosphotyrosine residue binding activity. Involved in immune response-regulating cell surface receptor signaling pathway. Predicted to be located in cell-cell junction. Predicted to be active in cytoplasm. Biomarker of endometriosis; hepatocellular carcinoma; lymphopenia; and type 1 diabetes mellitus. Orthologous to human VAV1 (vav guanine nucleotide exchange factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vav1 |
| Official Name | vav guanine nucleotide exchange factor 1 [Source:RGD Symbol;Acc:3951] |
| Ensembl ID | ENSRNOG00000050430 |
| Bio databases IDs | |
| Aliases | vav guanine nucleotide exchange factor 1 |
| Synonyms | p95 VAV, VAV, vav 1 oncogene, vav guanine nucleotide exchange factor 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Vav1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- pleckstrin Homology binding region
- transcription regulator
- Calponin homology domain
- phosphotyrosine binding
- protein binding
- CR domain
- Pleckstrin homology-like domain
- Src-homology 2 binding domain
- acidic domain
- RhoGEF domain
- inter-SH2 domain
- Sh3 domain binding motif
- Src Homology 3 domain superfamily
- RhoGEF
- protein kinase C conserved region 1 (C1 domain) superfamily
- guanyl-nucleotide exchange factor
- PH domain
- calponin homology (CH) domain superfamily
- cysteine-histidine rich domain
- Src homology 2 (SH2) domain
- zinc finger domain
- helix-loop-helix domain
- Dbl homology domain
- guanine nucleotide exchange factor domain
Pathways
Biological processes and signaling networks where the Vav1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- CD28 Signaling in T Helper Cells
- Cdc42 Signaling
- Ephrin A Signaling
- Ephrin B Signaling
- Fc Epsilon RI Signaling
- Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes
- G Protein Signaling Mediated by Tubby
- Gα12/13 Signaling
- iCOS-iCOSL Signaling in T Helper Cells
- Leukocyte Extravasation Signaling
- Natural Killer Cell Signaling
- PI3K Signaling in B Lymphocytes
- PKCθ Signaling in T Lymphocytes
- Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes
- T Cell Receptor Signaling
- Tec Kinase Signaling
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- androgenic alopecia
- anaphylaxis
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- ovarian cancer
- COVID-19
- cutaneous T-cell lymphoma
- skin cancer
role in cell
- cell death
- production in
- expression in
- phosphorylation in
- apoptosis
- cellular infiltration by
- proliferation
- quantity
- activation
- transendothelial migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- raft fractions
- Cytoplasm
- Plasma Membrane
- intercellular junctions
- cytosol
- synapse
- membrane rafts
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Vav1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- T cell costimulation
- regulation of cell size
- Fc-epsilon receptor signaling pathway
- Fc-gamma receptor signaling pathway involved in phagocytosis
- natural killer cell mediated cytotoxicity
- positive regulation of natural killer cell mediated cytotoxicity
- T cell differentiation
- reactive oxygen species metabolic process
- vascular endothelial growth factor receptor signaling pathway
- integrin-mediated signaling pathway
- regulation of small GTPase mediated signal transduction
- regulation of GTPase activity
- neutrophil chemotaxis
- cellular response to xenobiotic stimulus
- platelet activation
- cell migration
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphotyrosine binding
- protein binding
- metal ion binding
- guanyl-nucleotide exchange factor activity