Fn1 Gene Summary [Rat]
Enables mercury ion binding activity and protease binding activity. Involved in several processes, including cellular response to amyloid-beta; cellular response to mercury ion; and cellular response to platelet-derived growth factor stimulus. Located in basement membrane and extracellular space. Used to study diabetic angiopathy; hypertension; and renovascular hypertension. Biomarker of several diseases, including artery disease (multiple); calcium oxalate nephrolithiasis; iron deficiency anemia; membranoproliferative glomerulonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fn1 |
| Official Name | fibronectin 1 [Source:RGD Symbol;Acc:2624] |
| Ensembl ID | ENSRNOG00000014288 |
| Bio databases IDs | |
| Aliases | fibronectin 1 |
| Synonyms | cFn, CIG, E330027I09, ED-B, FIBNEC, Fibronectin, FIBRONECTIN 1, Fibronectin3 M1, Fibronectin i, FINC, FN, FN1 isoform 1, FNZ, GFND, GFND2, LETS, MSF, SMDCF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fn1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell-binding domain
- type III repeat domain
- gelatin binding domain
- variable domain
- IGD motif
- heparin binding domain
- fibrin-binding domain
- Fibronectin type 3 domain
- protease activator
- identical protein binding
- connecting segment-1
- DPPIV-binding domain
- Integrin alpha5 beta1 binding domain
- fibrin and heparin-binding domain
- Integrin alpha4 beta1 binding domain
- mercury ion binding
- central cell binding domain
- matrix assembly domain
- Iiics domain
- fibronectin-like domain
- beta-strand A of the fibronectin1 10FNIII Domain
- collagen binding domain
- heparin ii binding domain
- beta-strand B of the fibronectin1 10FNIII domain
- protease binding
- Hep III fibronectin domain
- extracellular matrix structural constituent
- RGD motif
- linker domain
- FN1
- protein binding
- receptor binding
- surface domain
- FN2
- integrin binding domain
- binding protein
- FN3
- integrin binding
- receptor agonist activity
- cryptic antiadhesive site
- Vegf binding domain
- gelatin- and collagen-binding domain
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Fn1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Actin Cytoskeleton Signaling
- Acute Phase Response Signaling
- Agranulocyte Adhesion and Diapedesis
- Granzyme A Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-17A Signaling in Fibroblasts
- ILK Signaling
- Osteoarthritis Pathway
- Phagosome Formation
- Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- edema
- adenoma formation
- epithelial neoplasia
- epithelial cancer
- cancer
- liver disease
- breast cancer
- kidney disease
- cirrhosis
role in cell
- biosynthesis in
- tyrosine phosphorylation in
- growth
- proliferation
- expression in
- motility
- invasion by
- migration
- cell viability
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- S-layer
- extracellular vesicles
- Cytoplasm
- cell surface
- cell periphery
- intracellular space
- basal compartment
- membrane surface
- focal adhesions
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- intercellular junctions
- ER-to-Golgi intermediate compartment
- basal cell surfaces
- apical cell surfaces
- endoplasmic reticulum lumen
- apical membrane
- basal membrane
- alpha granules
- multivesicular bodies
- fibrils
- extracellular matrix
- basal lamina
- exosomes
- plasma
- basement membrane
- glomerular basement membrane
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fn1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of cell proliferation
- nervous system development
- response to wounding
- cell adhesion
- heart development
- integrin-mediated signaling pathway
- wound healing
- angiogenesis
- positive regulation of fibroblast proliferation
- substrate adhesion-dependent cell spreading
- interaction with symbiont
- negative regulation of transforming growth factor beta production
- cell-matrix adhesion
- calcium-independent cell-matrix adhesion
- cell-substrate junction assembly
- positive regulation of axon extension
- acute-phase response
- regulation of ERK1 and ERK2 cascade
- regulation of protein phosphorylation
- positive regulation of gene expression
- endodermal cell differentiation
- peptide cross-linking
- positive regulation of protein kinase B signaling cascade
- integrin activation
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- endoplasmic reticulum-Golgi intermediate compartment
- extracellular region
- plasma membrane
- fibrinogen complex
- endoplasmic reticulum lumen
- basement membrane
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- extracellular matrix
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- peptidase activator activity
- protein binding
- proteoglycan binding
- collagen binding
- heparin binding
- protease binding
- integrin binding
- receptor binding
- extracellular matrix structural constituent