Stab1 Gene Summary [Rat]
Predicted to enable low-density lipoprotein particle binding activity; low-density lipoprotein particle receptor activity; and scavenger receptor activity. Predicted to be involved in cell-cell signaling; defense response to bacterium; and negative regulation of angiogenesis. Predicted to be located in plasma membrane. Orthologous to human STAB1 (stabilin 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Stab1 |
| Official Name | stabilin 1 [Source:RGD Symbol;Acc:2324745] |
| Ensembl ID | ENSRNOG00000018434 |
| Bio databases IDs | |
| Aliases | stabilin 1 |
| Synonyms | CLEVER-1, FEEL-1, FELE-1, FEX1, HRFT, LOC100363622, MFEEL-1, mKIAA0246, MS-1, SCARH2, stabilin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Stab1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Fasciclin domain
- scavenger receptor
- Link_Domain
- transmembrane domain
- GGA binding domain
- EGF domain
- protein binding
- low-density lipoprotein binding
- Extracellular link domain
- low-density lipoprotein receptor
- transporter
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute myeloid leukemia
- isolated hyperferritinemia
- carbon tetrachloride-induced liver fibrosis
- hyperferritinemia
- congestion
- congestive heart failure
- fibrosis
- hepatocellular carcinoma
- liver cancer
role in cell
- production in
- expression in
- replication in
- migration
- quantity
- number
- binding
- transendothelial migration
- sprouting angiogenesis by
- scavenging by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Stab1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of angiogenesis
- inflammatory response
- cell-cell signaling
- cell adhesion
- defense response to bacterium
- receptor-mediated endocytosis
Cellular Component
Where in the cell the gene product is active
- endocytic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein disulfide oxidoreductase activity
- calcium ion binding
- low-density lipoprotein receptor activity
- scavenger receptor activity
- hyaluronic acid binding
- low-density lipoprotein particle binding