Wwtr1 Gene Summary [Rat]
Predicted to enable protein homodimerization activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in several processes, including intracellular signal transduction; negative regulation of canonical Wnt signaling pathway; and positive regulation of cell differentiation. Predicted to act upstream of or within several processes, including SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; kidney development; and negative regulation of fat cell differentiation. Located in nucleus. Orthologous to human WWTR1 (WW domain containing transcription regulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wwtr1 |
| Official Name | WW domain containing transcription regulator 1 [Source:RGD Symbol;Acc:1559609] |
| Ensembl ID | ENSRNOG00000016617 |
| Bio databases IDs | |
| Aliases | WW domain containing transcription regulator 1 |
| Synonyms | 2310058J06Rik, 2610021I22Rik, DKFZp586I1419, TAZ, TRANSCRIPTIONAL COACTIVATOR with PDZ-binding MOTIF, WW domain containing transcription regulator 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Wwtr1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- Domain with 2 conserved Trp (W) residues
- transcription co-activator
- transcription co-repressor
- WW
- transcription cofactor
- protein homodimerization
- coiled-coil domain
- protein binding
- PDZ binding motif
- WW domain
- phosphorylation site
Pathways
Biological processes and signaling networks where the Wwtr1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- cancer
- hepatic injury
- fibrosis
- neoplasia
- metastasis
- abdominal aortic aneurysm
- neoplastic cell transformation
- interstitial fibrosis
- Huntington disease
role in cell
- proliferation
- apoptosis
- cell death
- survival
- expression in
- activation in
- growth
- cell viability
- tumorigenicity
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- Plasma Membrane
- intercellular junctions
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Wwtr1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organism growth
- positive regulation of cell proliferation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- negative regulation of protein kinase activity
- heart process
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of epithelial to mesenchymal transition
- mesenchymal cell differentiation
- osteoblast differentiation
- stem cell division
- regulation of metanephric nephron tubule epithelial cell differentiation
- positive regulation of protein localization to nucleus
- kidney morphogenesis
- cilium morphogenesis
- SMAD protein signal transduction
- negative regulation of fat cell differentiation
- regulation of transcription, DNA-dependent
- tissue homeostasis
- negative regulation of canonical Wnt receptor signaling pathway
- glomerulus development
- negative regulation of protein phosphorylation
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- hippo signaling cascade
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor complex
- nuclear body
- cytoplasm
- cytosol
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription cofactor activity
- protein binding
- protein homodimerization activity
- transcription coactivator activity
- transcription corepressor activity