Cd40 Gene Summary [Rat]
Enables antigen binding activity and protein domain specific binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipopolysaccharide; and response to type II interferon. Located in several cellular components, including cell surface; neuronal cell body; and varicosity. Used to study several diseases, including Ehrlich tumor carcinoma; artery disease (multiple); colitis; membranous glomerulonephritis; and obesity. Biomarker of asthma; atherosclerosis; and perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); end stage renal disease; hyperimmunoglobulin syndrome (multiple); and non-Hodgkin lymphoma (multiple). Orthologous to human CD40 (CD40 molecule). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cd40 |
| Official Name | CD40 molecule [Source:RGD Symbol;Acc:619830] |
| Ensembl ID | ENSRNOG00000018488 |
| Bio databases IDs | |
| Aliases | CD40 molecule |
| Synonyms | Bp50, CD40 antigen, CD40L, CD40L receptor, CD40 molecule, CD40 receptor, CDW40, GP39, HIGM1, IGM, IMD3, p50, T-BAM, Tnf receptor member 5, TNFRSF5, TRAP |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cd40 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Traf2/3 binding domain
- proline rich domain
- TRAF binding domain
- cytoplasmic domain
- homodimerization domain
- intracellular domain
- transmembrane receptor
- cysteine rich domain
- TRAF1/2/3 binding domain
- ubiquitin protein ligase binding
- traf2 binding domain
- extracellular domain
- signaling receptor activity
- TNF homology domain
- ectodomain
- nuclear localization sequence
- enzyme binding
- antigen binding
- TNFR/NGFR cysteine-rich region
- protein domain specific binding
- TRAF3-binding domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- TRAF6 binding domain
- protein binding domain
- transmembrane domain
- cytosolic tail domain
Pathways
Biological processes and signaling networks where the Cd40 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Allograft Rejection Signaling
- Atherosclerosis Signaling
- Autoimmune Thyroid Disease Signaling
- B Cell Development
- CD40 Signaling
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Dendritic Cell Maturation
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- IL-12 Signaling and Production in Macrophages
- Neuroinflammation Signaling Pathway
- NF-κB Signaling
- PI3K Signaling in B Lymphocytes
- Primary Immunodeficiency Signaling
- Systemic Lupus Erythematosus Signaling
- T Helper Cell Differentiation
- Th1 and Th2 Activation Pathway
- Th1 Pathway
- Th2 Pathway
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- epithelial cancer
- cancer
- obesity
- mechanical hypersensitivity
- late-onset preeclampsia
- contact hypersensitivity
- rheumatoid arthritis
- diffuse large B-cell lymphoma
- B-cell non-Hodgkin disease
role in cell
- production in
- stimulation
- proliferation
- activation in
- killing
- apoptosis
- cell death
- survival
- morphology
- phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- nuclear fraction
- raft fractions
- axon component
- intracellular membrane-bounded organelle
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- membrane surface
- cellular membrane
- Nucleus
- plasma membrane extracellular face
- nucleoplasm
- nuclear envelope
- neurites
- sarcolemma
- membrane rafts
- perikaryon
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cd40 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive regulation of protein kinase C signaling cascade
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of tyrosine phosphorylation of STAT protein
- B cell activation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of GTPase activity
- positive regulation of angiogenesis
- defense response to protozoan
- protein kinase B signaling cascade
- inflammatory response
- defense response to virus
- cellular response to tumor necrosis factor
- positive regulation of endothelial cell apoptotic process
- platelet activation
- B cell mediated immunity
- response to cobalamin
- macromolecular complex assembly
- response to interferon-gamma
- B cell proliferation
- positive regulation of isotype switching to IgG isotypes
- positive regulation of blood vessel endothelial cell migration
- cellular calcium ion homeostasis
- positive regulation of interleukin-12 production
- CD40 signaling pathway
- cellular response to mechanical stimulus
- cellular response to lipopolysaccharide
- immune response-regulating cell surface receptor signaling pathway
- positive regulation of protein phosphorylation
- cellular response to interleukin-1
- positive regulation of B cell proliferation
- cellular response to erythropoietin
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- varicosity
- intracellular membrane-bounded organelle
- external side of plasma membrane
- neuronal cell body
- CD40 receptor complex
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- protein binding
- ubiquitin protein ligase binding
- antigen binding
- signaling receptor activity
- enzyme binding