Ccl3 Gene Summary [Rat]
Enables chemokine activity. Involved in several processes, including neutrophil chemotaxis; positive regulation of cytosolic calcium ion concentration; and positive regulation of osteoclast differentiation. Predicted to be located in cytosol and extracellular region. Predicted to be active in extracellular space. Biomarker of several diseases, including Chagas disease; anterior uveitis; nephritis (multiple); renal fibrosis; and status epilepticus. Human ortholog(s) of this gene implicated in human immunodeficiency virus infectious disease. Orthologous to several human genes including CCL3 (C-C motif chemokine ligand 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ccl3 |
| Official Name | C-C motif chemokine ligand 3 [Source:RGD Symbol;Acc:3647] |
| Ensembl ID | ENSRNOG00000011205 |
| Bio databases IDs | |
| Aliases | C-C motif chemokine ligand 3 |
| Synonyms | C-C motif chemokine ligand 3, G0S19-1, L2g25b, LD78alpha, MIP-1a, MIP1-(a), MIP-1alpha, MIP1-α, Mnp, Scya3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ccl3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CCR chemokine receptor binding
- chemokine
- chemoattractant
- Small cytokines (intecrine/chemokine), interleukin-8 like
- protein binding
- cytokine
- phospholipase activator
- identical protein binding
Pathways
Biological processes and signaling networks where the Ccl3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agranulocyte Adhesion and Diapedesis
- CCR5 Signaling in Macrophages
- Communication between Innate and Adaptive Immune Cells
- Differential Regulation of Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Glucocorticoid Receptor Signaling
- Granulocyte Adhesion and Diapedesis
- Neuroinflammation Signaling Pathway
- Pathogenesis of Multiple Sclerosis
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatic fibrosis
- myocardial infarction
- dextran sodium sulfate-induced colitis
- Alzheimer disease
- diabetes mellitus
- hypersensitive reaction
- acute lung injury
- adjuvant arthritis
- insulitis
- pancreatic ductal adenocarcinoma
role in cell
- apoptosis
- migration
- activation in
- formation
- growth
- chemotaxis
- activation
- cellular infiltration by
- adhesion
- infiltration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- cytosol
- exosomes