Hgf Gene Summary [Rat]
Enables growth factor activity. Involved in several processes, including liver regeneration; positive regulation of angiogenesis; and positive regulation of myelination. Located in extracellular space. Used to study brain infarction. Biomarker of cholangiocarcinoma. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autosomal recessive nonsyndromic deafness 39; eye disease (multiple); neuropathy (multiple); and scleroderma (multiple). Orthologous to human HGF (hepatocyte growth factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hgf |
| Official Name | hepatocyte growth factor [Source:RGD Symbol;Acc:2794] |
| Ensembl ID | ENSRNOG00000007027 |
| Bio databases IDs | |
| Aliases | hepatocyte growth factor |
| Synonyms | C230052L06Rik, DFNB39, F-TCF, hepatocyte growth factor, HGFB, HGF/SF, HPTA, NK1, NK2, SF, SF/HGF |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hgf often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PAN_APPLE
- KR
- dimerization domain
- Trypsin-like serine protease
- Tryp_SPc
- constant light chain domain
- catalytic domain
- chemoattractant
- serine protease domain
- protein binding
- identical protein binding
- growth factor
- trypsin
- binding protein
- PAN domain
Pathways
Biological processes and signaling networks where the Hgf gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Autophagy
- CREB Signaling in Neurons
- Docosahexaenoic Acid (DHA) Signaling
- Ephrin A Signaling
- Epithelial Adherens Junction Signaling
- FGF Signaling
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HGF Signaling
- HIF1α Signaling
- IL-7 Signaling Pathway
- Macropinocytosis Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Remodeling of Epithelial Adherens Junctions
- Renal Cell Carcinoma Signaling
- Role of Tissue Factor in Cancer
- STAT3 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- obesity
- gastric cancer
- hepatocellular carcinoma
- metastatic gastroesophageal junction adenocarcinoma
- locally advanced gastric adenocarcinoma
- lung cancer
- metastatic gastric cancer
- plasma cell myeloma
role in cell
- expression in
- transactivation in
- activation in
- proliferation
- infiltration by
- synthesis in
- binding in
- transcription in
- phosphorylation in
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- plasma membrane fraction
- detergent-insoluble fractions
- detergent resistant lipid raft fraction
- intracellular compartment
- Cytoplasm
- cell surface
- intracellular space
- alpha granules
- specific granules
- extracellular matrix
- microsomal membrane
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hgf gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive chemotaxis
- positive regulation of osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
- mitotic cell cycle
- cell chemotaxis
- epithelial cell proliferation
- liver development
- negative regulation of peptidyl-serine phosphorylation
- skeletal muscle cell proliferation
- positive regulation of DNA biosynthetic process
- negative regulation of release of cytochrome c from mitochondria
- cell morphogenesis
- negative regulation of inflammatory response
- positive regulation of MAPK cascade
- regulation of p38MAPK cascade
- hepatocyte growth factor receptor signaling pathway
- negative regulation of interleukin-6 production
- negative regulation of autophagy
- cellular response to hepatocyte growth factor stimulus
- negative regulation of apoptotic process
- myoblast proliferation
- proteolysis
- positive regulation of protein phosphorylation
- epithelial to mesenchymal transition
- positive regulation of interleukin-10 production
- positive regulation of protein kinase B signaling cascade
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- platelet alpha granule lumen
- extracellular space
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- identical protein binding
- protein binding
- serine-type endopeptidase activity
- endopeptidase activity
- chemoattractant activity
- receptor binding