Creg1 Gene Summary [Mouse]
Predicted to enable insulin-like growth factor receptor binding activity. Acts upstream of or within several processes, including endocytosis; lysosomal lumen acidification; and regulation of DNA-templated transcription. Located in endosome and lysosome. Part of transcription regulator complex. Is expressed in central nervous system; liver; and ureter. Orthologous to human CREG1 (cellular repressor of E1A stimulated genes 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Creg1 |
| Official Name | cellular repressor of E1A-stimulated genes 1 [Source:MGI Symbol;Acc:MGI:1344382] |
| Ensembl ID | ENSMUSG00000040713 |
| Bio databases IDs | |
| Aliases | cellular repressor of E1A-stimulated genes 1 |
| Synonyms | cellular repressor of E1A-stimulated genes 1, CREG, Riken clone 2510009j19 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Creg1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pyridoxine 5'-phosphate (PNP) oxidase-like and flavin reductase-like proteins
- transcription regulator
- transcription co-repressor
- transcription factor binding
- insulin-like growth factor receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leiomyomatosis
- cardiac fibrosis
- heart disease
- acute graft-vs-host disease
- uterine leiomyoma
- cardiac hypertrophy
- hepatic injury
- hepatic steatosis
- early onset hypertension
- atrophic gastritis
regulated by
- lipopolysaccharide
- sirolimus
- palmitic acid
- tretinoin
- dexamethasone
- 1,2-dithiole-3-thione
- ethanol
- tetradecanoylphorbol acetate
- TSC2
- methylprednisolone
role in cell
- proliferation
- expression in
- apoptosis
- differentiation
- phosphorylation in
- growth
- autophagy by
- cell cycle progression
- senescence
- dysfunction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- azurophil granule lumen
- Extracellular Space
- cell periphery
- endosomes
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Creg1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- autophagy
- lysosomal lumen acidification
- endocytosis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- extracellular space
- endosome
- extracellular vesicular exosome
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- transcription corepressor activity