Fbxo2 Gene Summary [Mouse]
Enables amyloid-beta binding activity; carbohydrate binding activity; and denatured protein binding activity. Involved in protein catabolic process; protein ubiquitination; and regulation of protein catabolic process at postsynapse, modulating synaptic transmission. Acts upstream of or within ERAD pathway; regulation of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Located in cytosol and dendritic spine. Part of SCF ubiquitin ligase complex. Is active in glutamatergic synapse. Is expressed in brain; testis; and vestibulo-cochlear ganglion. Orthologous to human FBXO2 (F-box protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fbxo2 |
| Official Name | F-box protein 2 [Source:MGI Symbol;Acc:MGI:2446216] |
| Ensembl ID | ENSMUSG00000041556 |
| Bio databases IDs | |
| Aliases | F-box protein 2 |
| Synonyms | FBG1, F-box protein 2, Fbs1, Fbs2, FBX2, NFB42, OCP1, PRPL4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fbxo2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- F-box domain superfamily
- ubiquitin-protein transferase activity
- F-box associated region
- enzyme
- protein binding
- carbohydrate binding
- beta-amyloid binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian cancer
- neoplasia
- hearing loss
- organismal death
- age-related hearing loss
- cognitive impairment
role in cell
- apoptosis
- expression in
- migration
- proliferation
- invasion by
- degradation in
- degeneration
- abnormal morphology
- synaptic transmission
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic spine
- glutaminergic synapse
- somatodendritic region
- Nucleus
- Plasma Membrane
- cytosol
- dendritic spines
- axons
- dendrites
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fbxo2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein catabolic process
- protein modification process
- negative regulation of cell proliferation
- proteolysis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- regulation of protein ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- dendritic spine
- cytosol
- endoplasmic reticulum
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- carbohydrate binding
- denatured protein binding
- beta-amyloid binding