CREG1 Gene Summary [Human]
The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CREG1 |
| Official Name | cellular repressor of E1A stimulated genes 1 [Source:HGNC Symbol;Acc:HGNC:2351] |
| Ensembl ID | ENSG00000143162 |
| Bio databases IDs | |
| Aliases | cellular repressor of E1A stimulated genes 1 |
| Synonyms | cellular repressor of E1A-stimulated genes 1, CREG, Riken clone 2510009j19 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CREG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pyridoxine 5'-phosphate (PNP) oxidase-like and flavin reductase-like proteins
- transcription regulator
- transcription co-repressor
- transcription factor binding
- insulin-like growth factor receptor binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- leiomyomatosis
- cardiac fibrosis
- heart disease
- acute graft-vs-host disease
- uterine leiomyoma
- cardiac hypertrophy
- hepatic injury
- hepatic steatosis
- early onset hypertension
- atrophic gastritis
regulated by
- lipopolysaccharide
- sirolimus
- palmitic acid
- tretinoin
- dexamethasone
- 1,2-dithiole-3-thione
- ethanol
- tetradecanoylphorbol acetate
- TSC2
- methylprednisolone
role in cell
- proliferation
- expression in
- apoptosis
- differentiation
- phosphorylation in
- growth
- autophagy by
- cell cycle progression
- senescence
- dysfunction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- azurophil granule lumen
- Extracellular Space
- cell periphery
- endosomes
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CREG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription, DNA-dependent
- autophagy
- lysosomal lumen acidification
- endocytosis
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- extracellular space
- endosome
- extracellular vesicular exosome
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- transcription corepressor activity