Itgb3bp Gene Summary [Rat]
Predicted to be involved in several processes, including CENP-A containing chromatin assembly; apoptotic process; and regulation of DNA-templated transcription. Predicted to act upstream of or within negative regulation of epithelial cell apoptotic process and positive regulation of epithelial cell proliferation. Predicted to be located in kinetochore. Predicted to be part of inner kinetochore. Predicted to be active in nucleoplasm. Orthologous to human ITGB3BP (integrin subunit beta 3 binding protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Itgb3bp |
| Official Name | integrin subunit beta 3 binding protein [Source:RGD Symbol;Acc:1310044] |
| Ensembl ID | ENSRNOG00000009116 |
| Bio databases IDs | |
| Aliases | integrin subunit beta 3 binding protein |
| Synonyms | 4930471O16RIK, AU022583, beta 3 endonexin, BX005053.1, CENP-R, HSU37139, integrin beta 3 binding protein (beta3-endonexin), integrin subunit beta 3 binding protein, integrin subunit β 3 binding protein, integrin β 3 binding protein (beta3-endonexin), LOC103692425, NRIF3, TAP20, β 3 endonexin |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Itgb3bp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- LXXLL motif
- protein binding
- death domain 1
- Kinetochore component, CENP-R
Pathways
Biological processes and signaling networks where the Itgb3bp gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- androgenic alopecia
- neoplasia
- non-insulin-dependent diabetes mellitus
- age-related hearing loss
regulates
- ITGB3BP
- RXR
- RAR/RXR/retinoic acid
role in cell
- proliferation
- apoptosis
- adhesion
- killing
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cellular membrane
- cytosol
- nucleoplasm
- kinetochores
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Itgb3bp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- signal transduction
- apoptotic process
- chromosome segregation
- regulation of transcription, DNA-dependent
- cell adhesion
- positive regulation of epithelial cell proliferation
- CenH3-containing nucleosome assembly at centromere
Cellular Component
Where in the cell the gene product is active
- nucleus
- condensed chromosome inner kinetochore
- cytoplasm
- membrane
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding