Fgfr3 Gene Summary [Rat]
Enables fibroblast growth factor binding activity and fibroblast growth factor receptor activity. Involved in cell-cell signaling; fibroblast growth factor receptor signaling pathway; and positive regulation of cell population proliferation. Located in cell surface. Biomarker of chondrosarcoma. Human ortholog(s) of this gene implicated in several diseases, including Human papillomavirus infectious disease; SADDAN; acanthosis nigricans; bone disease (multiple); and carcinoma (multiple). Orthologous to human FGFR3 (fibroblast growth factor receptor 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgfr3 |
| Official Name | fibroblast growth factor receptor 3 [Source:RGD Symbol;Acc:620714] |
| Ensembl ID | ENSRNOG00000016818 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor receptor 3 |
| Synonyms | ACH, CD333, CEK2, Fgfr3 iiib, fibroblast growth factor receptor 3, Flg-2, FR3, HBGFR, HSFGFR3EX, JTK4, Mfr3, sam3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fgfr3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein-tyrosine kinase
- Protein kinase domain
- identical protein binding
- activation loop
- Immunoglobulin like
- intracellular domain
- immunoglobulin-like protein domain
- extracellular loop
- membrane-proximal domain
- Tyrosine kinase, catalytic domain
- Immunoglobulin V-set domain
- transmembrane receptor
- extracellular domain
- Protein kinase (unclassified specificity)
- Protein tyrosine and serine/threonine kinase
- immunoglobulin domain
- Immunoglobulin I-set domain
- protein binding
- RNA binding
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- fibroblast growth factor receptor
- Protein Kinases, catalytic domain
- fibroblast growth factor binding
- transmembrane domain
- tyrosine kinase domain
Pathways
Biological processes and signaling networks where the Fgfr3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Adipogenesis pathway
- Bladder Cancer Signaling
- CREB Signaling in Neurons
- FGF Signaling
- Human Embryonic Stem Cell Pluripotency
- IL-15 Production
- NF-κB Signaling
- Osteoarthritis Pathway
- PTEN Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Sperm Motility
- STAT3 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- urothelial carcinoma
- urothelial cancer
- metastatic renal clear cell adenocarcinoma
- renal cancer
- primary peritoneal cancer
- non-small cell lung cancer
- metastatic urothelial carcinoma
- ovarian cancer
- advanced renal clear cell adenocarcinoma
- epithelial ovarian cancer
role in cell
- apoptosis
- activation in
- expression in
- growth
- proliferation
- differentiation
- phosphorylation in
- cell viability
- migration
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- perinuclear region
- cellular membrane
- focal adhesions
- Nucleus
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- cytoplasmic face of plasma membrane
- neuromuscular junctions
- transport vesicles
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fgfr3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- bone mineralization
- multicellular organismal development
- positive regulation of cell proliferation
- cell-cell signaling
- bone morphogenesis
- chondrocyte differentiation
- fibroblast growth factor receptor signaling pathway
- transmembrane receptor protein tyrosine kinase signaling pathway
- positive regulation of MAPK cascade
- positive regulation of tyrosine phosphorylation of STAT protein
- JAK-STAT cascade
- MAPK cascade
- skeletal system development
- endochondral bone growth
- positive regulation of phospholipase activity
- negative regulation of developmental growth
- positive regulation of ERK1 and ERK2 cascade
- endochondral ossification
- chondrocyte proliferation
- positive regulation of kinase activity
- bone maturation
- positive regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- focal adhesion
- endoplasmic reticulum
- Golgi apparatus
- receptor complex
- transport vesicle
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- ATP binding
- fibroblast growth factor-activated receptor activity
- identical protein binding
- protein tyrosine kinase activity
- protein binding
- fibroblast growth factor binding