Hras Gene Summary [Rat]
Predicted to enable several functions, including GTPase activity; guanyl ribonucleotide binding activity; and phospholipase C activator activity. Involved in several processes, including Ras protein signal transduction; positive regulation of DNA replication; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hras |
| Official Name | HRas proto-oncogene, GTPase [Source:RGD Symbol;Acc:2827] |
| Ensembl ID | ENSRNOG00000016611 |
| Bio databases IDs | |
| Aliases | HRas proto-oncogene, GTPase |
| Synonyms | C-BAS/HAS, C-HA-RAS, C-HA-RAS1, C-H-RAS, c-rasHa, CTLO, HAMSV, Ha-ras, Harvey-ras, Harvey rat sarcoma virus oncogene, HRAS1, H-RASIDX, HRas proto-oncogene, GTPase, Kras2, RAS, RASH1, RAS HA, V-H-RAS |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hras often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- effector loop
- Ras family
- protein binding activity, bridging
- enzyme
- effector domain
- phospholipase activator
- Ras of Complex, Roc, domain of DAPkinase
- GTP binding motif, P-loop
- Rho (Ras homology) subfamily of Ras-like small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
- farnesylation site
- GTP binding domain
- GTP binding domain-switch II region
- activation domain
- palmitoylation site
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- GTPase
- protein binding
- prenylation site
- Ras subfamily of RAS small GTPases
- GTP binding
- binding protein
- CAAX box
- small GTP-binding protein domain
- GTPase domain
- GDP binding
- Rab subfamily of small GTPases
- hypervariable region
Pathways
Biological processes and signaling networks where the Hras gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Agrin Interactions at Neuromuscular Junction
- Angiopoietin Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Bladder Cancer Signaling
- Chemokine Signaling
- CNTF Signaling
- CXCR4 Signaling
- ErbB Signaling
- Glucocorticoid Receptor Signaling
- GM-CSF Signaling
- HER-2 Signaling in Breast Cancer
- HGF Signaling
- JAK/Stat Signaling
- LPS-stimulated MAPK Signaling
- Neuregulin Signaling
- Neurotrophin/TRK Signaling
- Oncostatin M Signaling
- PDGF Signaling
- PPAR Signaling
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- TGF-β Signaling
- Thyroid Cancer Signaling
- UVC-Induced MAPK Signaling
- VEGF Family Ligand-Receptor Interactions
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- testicular germ cell cancer
- breast cancer
- breast carcinoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- sebaceous naevi
- neoplasia
- liver neoplasia
- tumorigenesis
- neoplastic cell transformation
role in cell
- expression in
- binding in
- cell death
- activation in
- production in
- apoptosis
- migration
- phosphorylation in
- proliferation
- growth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- plasma membrane fraction
- nuclear fraction
- membrane fraction
- pH resistant lipid raft fraction
- glutaminergic synapse
- Cytoplasm
- cell periphery
- perinuclear region
- cellular membrane
- Nucleus
- basal bodies
- Golgi Apparatus
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- cytoplasmic face of plasma membrane
- endoplasmic reticulum membrane
- membrane ruffles
- caveolar membranes
- caveolae
- Golgi membrane
- nucleoplasm
- synaptosomes
- pedicels
- recycling endosomes
- peri-Golgi vesicles
- secretory granules
- membrane rafts
- microvilli
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hras gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of MAP kinase activity
- positive regulation of protein targeting to membrane
- Schwann cell development
- insulin receptor signaling pathway
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- cellular senescence
- myelination
- intrinsic apoptotic signaling pathway
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of GTPase activity
- negative regulation of neuron apoptotic process
- defense response to protozoan
- fibroblast proliferation
- MAPK cascade
- chemotaxis
- regulation of long-term neuronal synaptic plasticity
- positive regulation of fibroblast proliferation
- positive regulation of interferon-gamma production
- regulation of cell cycle
- positive regulation of epithelial cell proliferation
- T cell receptor signaling pathway
- neuron apoptotic process
- positive regulation of miRNA metabolic process
- negative regulation of GTPase activity
- positive regulation of wound healing
- oncogene-induced senescence
- signal transduction
- T-helper 1 type immune response
- cell surface receptor signaling pathway
- Ras protein signal transduction
- positive regulation of MAPK cascade
- positive regulation of ruffle assembly
- endocytosis
- regulation of cell proliferation
- organ morphogenesis
- regulation of transcription from RNA polymerase II promoter
- adipose tissue development
- negative regulation of gene expression
- cellular response to gamma radiation
- regulation of actin cytoskeleton organization
- positive regulation of JNK cascade
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of protein phosphorylation
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear region of cytoplasm
- cytoplasm
- cytosol
- Golgi membrane
- Golgi apparatus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- protein anchor
- small monomeric GTPase activity
- GDP binding