St8sia2 Gene Summary [Rat]
The protein encoded by this gene is a type II membrane protein that is thought to catalyze the transfer of sialic acid from CMP-sialic acid to N-linked oligosaccharides and glycoproteins. The encoded protein may be found in the Golgi apparatus and may be involved in the production of polysialic acid, a modulator of the adhesive properties of neural cell adhesion molecule (NCAM1). This protein is a member of glycosyltransferase family 29. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | St8sia2 |
| Official Name | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 [Source:RGD Symbol;Acc:621843] |
| Ensembl ID | ENSRNOG00000012031 |
| Bio databases IDs | |
| Aliases | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2 |
| Synonyms | alpha-2,8-sialyltransferase 8B, HsT19690, N-glycan alpha-2,8-sialyltransferase, N-glycan α-2,8-sialyltransferase, Sialyltransferase X, SIAT8-B, ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2, ST8SIA-II, ST8 α-N-acetyl-neuraminide α-2,8-sialyltransferase 2, STX, α-2,8-sialyltransferase 8B |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat St8sia2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase
- sialyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- vertebral fracture
- allergic rhinitis
- Huntington disease
- motor dysfunction or movement disorder
- Cornelia de Lange syndrome
- hydrocephalus
role in cell
- growth
- apoptosis
- loss
- differentiation
- migration
- cell death
- number
- formation
- abnormal morphology
- gating in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- perinuclear region
- Golgi Apparatus
- cytosol
- Golgi membrane
- nucleoplasm
- recycling endosomes
- early endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat St8sia2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein modification process
- carbohydrate metabolic process
- N-glycan processing
- response to cocaine
- protein glycosylation
- nervous system development
- oligosaccharide metabolic process
- positive regulation of synapse assembly
- positive regulation of neuron apoptotic process
- ganglioside biosynthetic process
Cellular Component
Where in the cell the gene product is active
- early endosome
- perinuclear region of cytoplasm
- Golgi apparatus
- Golgi membrane
- recycling endosome
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- sialic acid binding
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity