Pax3 Gene Summary [Rat]
Enables HMG box domain binding activity. Predicted to be involved in nervous system development and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nervous system development; regulation of somitogenesis; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Human ortholog(s) of this gene implicated in Waardenburg syndrome; Waardenburg syndrome type 1; Waardenburg syndrome type 3; alveolar rhabdomyosarcoma; and craniofacial-deafness-hand syndrome. Orthologous to human PAX3 (paired box 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pax3 |
| Official Name | paired box 3 [Source:RGD Symbol;Acc:620431] |
| Ensembl ID | ENSRNOG00000013670 |
| Bio databases IDs | |
| Aliases | paired box 3 |
| Synonyms | CDHS, HUP2, paired box 3, Sp, Splchl2, splotch, WS1, WS3 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pax3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Paired box protein 7
- transcription regulator
- DNA binding domain
- alpha helix
- HTH_ARSR
- octapeptide domain
- transcription activation domain
- transcription factor binding
- chromatin binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- HTH_CRP
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- double-stranded DNA binding
- 'Paired box' domain
- homeodomain
- transcription factor activity
- Paired Box domain
Pathways
Biological processes and signaling networks where the Pax3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- alveolar rhabdomyosarcoma
- Waardenburg syndrome type 1
- Waardenburg syndrome type 3
- tumorigenesis
- Waardenburg syndrome
- alopecia
- soft tissue sarcoma cancer
- cholesteatoma
- idiopathic scoliosis
role in cell
- apoptosis
- growth
- proliferation
- migration
- expression in
- binding in
- colony formation
- invasion by
- quantity
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pax3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle organ development
- sensory perception of sound
- positive regulation of transcription, DNA-dependent
- apoptotic process
- nervous system development
- anatomical structure development
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
- organ morphogenesis
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- HMG box domain binding
- sequence-specific DNA binding transcription factor activity
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity