Pcdh1 Gene Summary [Rat]
Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to be located in cell junction; nucleolus; and nucleoplasm. Predicted to be active in plasma membrane. Orthologous to human PCDH1 (protocadherin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcdh1 |
| Official Name | protocadherin 1 [Source:RGD Symbol;Acc:1308490] |
| Ensembl ID | ENSRNOG00000060410 |
| Bio databases IDs | |
| Aliases | protocadherin 1 |
| Synonyms | 2010005A06RIK, AXIAL PROTOCADHERIN, Pc1, PC42, PCDH42, protocadherin 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Pcdh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytoplasmic domain
- Cadherin-like
- Cadherin repeat-like domain
- protein binding
- Protocadherin
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- idiopathic pulmonary fibrosis
- organismal death
- insomnia
- Wilms tumorigenesis
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
- ductal pancreatic cancer
role in cell
- proliferation
- expression in
- growth
- migration
- adhesion
- aggregation
- interaction
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell junction
- intracellular membrane-bounded organelle
- cell surface
- intercellular junctions
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Pcdh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-cell signaling
- nervous system development
- cell adhesion
- homophilic cell adhesion
Cellular Component
Where in the cell the gene product is active
- cell-cell junction
- intracellular membrane-bounded organelle
- cell junction
- nucleolus
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- calcium ion binding