Nmu Gene Summary [Rat]
Enables type 1 neuromedin U receptor binding activity and type 2 neuromedin U receptor binding activity. Involved in several processes, including negative regulation of digestive system process; positive regulation of cell communication; and positive regulation of sensory perception of pain. Acts upstream of or within neuropeptide signaling pathway. Located in terminal bouton. Used to study obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMU (neuromedin U). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Nmu |
| Official Name | neuromedin U [Source:RGD Symbol;Acc:68388] |
| Ensembl ID | ENSRNOG00000002164 |
| Bio databases IDs | |
| Aliases | neuromedin U |
| Synonyms | neuromedin U, NMU-23, NMU25, Nmu-r1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Nmu often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neuromedin U receptor binding
- protein binding
- receptor binding
- Neuromedin U
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- edema
- ulcerative colitis
- endometrial adenocarcinoma
- endometrial adenocarcinoma formation
- arthritis
- hyperphagia
- urothelial bladder carcinoma
- transitional cell bladder cancer
- albuminuria
role in cell
- expression in
- migration
- activation in
- growth
- phosphorylation in
- production in
- number
- cellular infiltration by
- quantity
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- axon terminals
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Nmu gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuropeptide signaling pathway
- G-protein coupled receptor signaling pathway
- temperature homeostasis
- positive regulation of synaptic transmission
- energy homeostasis
- regulation of grooming behavior
- regulation of feeding behavior
- positive regulation of smooth muscle contraction
Cellular Component
Where in the cell the gene product is active
- terminal button
- extracellular region
Molecular Function
What the gene product does at the molecular level
- neuromedin U receptor binding
- protein binding
- type 1 neuromedin U receptor binding
- receptor binding
- type 2 neuromedin U receptor binding