Ifit3 Gene Summary [Rat]
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including antiviral innate immune response; negative regulation of apoptotic process; and response to stilbenoid. Predicted to act upstream of or within cellular response to interferon-beta and response to bacterium. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Orthologous to human IFIT3 (interferon induced protein with tetratricopeptide repeats 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifit3 |
| Official Name | interferon-induced protein with tetratricopeptide repeats 3 [Source:RGD Symbol;Acc:1359681] |
| Ensembl ID | ENSRNOG00000022839 |
| Bio databases IDs | |
| Aliases | interferon-induced protein with tetratricopeptide repeats 3 |
| Synonyms | CIG-41, CIG-49, GARG-49, IFI60, IFI-60K, IFIT4, interferon-induced protein with tetratricopeptide repeats 3, IRG2, ISG-561, ISG60, P60, RIG-G |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Ifit3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Ifit3 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- dermatomyositis
- diffuse cutaneous systemic sclerosis
- plasma cell myeloma
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- tuberculosis
- uterine leiomyoma
- leiomyomatosis
role in cell
- proliferation
- migration
- growth
- apoptosis
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Ifit3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- negative regulation of apoptotic process
- defense response to virus
- response to virus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding