Hnrnpd Gene Summary [Rat]
Enables several functions, including histone deacetylase binding activity; mRNA 3'-UTR AU-rich region binding activity; and minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including cellular response to estradiol stimulus; cellular response to nitric oxide; and positive regulation of macromolecule metabolic process. Is active in glutamatergic synapse and postsynaptic density. Used to study uremia. Biomarker of hepatocellular carcinoma. Orthologous to human HNRNPD (heterogeneous nuclear ribonucleoprotein D). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnrnpd |
| Official Name | heterogeneous nuclear ribonucleoprotein D [Source:RGD Symbol;Acc:620365] |
| Ensembl ID | ENSRNOG00000002292 |
| Bio databases IDs | |
| Aliases | heterogeneous nuclear ribonucleoprotein D |
| Synonyms | AUF1, AUF1A, C230004L04, heterogeneous nuclear ribonucleoprotein D, hnRNP C like, hnRNPD0, HnRNP UP2, HNRPD |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Hnrnpd often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- mRNA 3' UTR binding
- RNA recognition motif
- mRNA binding
- histone deacetylase binding
- chromatin binding
- protein binding
- telomeric DNA binding
- RNA-binding domain
- RNA binding
- AT DNA binding
Pathways
Biological processes and signaling networks where the Hnrnpd gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- plexiform neurofibroma
- glioblastoma
- pancreatic cancer
- growth failure
- glioblastoma cancer
- tumorigenesis
- bleeding
- neurodevelopmental disorder
- infection by bacteria
role in cell
- expression in
- degradation in
- growth
- phosphorylation in
- activation in
- activation
- function
- senescence
- response by
- nuclear import in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- Cytoplasm
- ribosome
- polysomes
- cytoplasmic aggregates
- cytosol
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- nuclear speckles
- synapse
- chromatin
- postsynaptic density
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Hnrnpd gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 3'-UTR-mediated mRNA destabilization
- positive regulation of translation
- negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- cerebellum development
- regulation of transcription, DNA-dependent
- RNA processing
- regulation of circadian rhythm
- RNA catabolic process
- negative regulation of gene expression
- cellular response to amino acid stimulus
- cellular response to estradiol stimulus
- circadian regulation of translation
- positive regulation of cytoplasmic translation
- positive regulation of transcription, DNA-dependent
- liver development
- response to calcium ion
- cellular response to nitric oxide
- regulation of gene expression
- response to electrical stimulus
- CRD-mediated mRNA stabilization
- regulation of telomere maintenance
Cellular Component
Where in the cell the gene product is active
- nucleus
- postsynaptic density
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- histone deacetylase binding
- mRNA 3'-UTR AU-rich region binding
- telomeric DNA binding
- AT DNA binding
- chromatin binding