Riok1 Gene Summary [Rat]
Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in maturation of SSU-rRNA and positive regulation of rRNA processing. Predicted to be part of methyltransferase complex and preribosome, small subunit precursor. Predicted to be active in cytosol. Orthologous to human RIOK1 (RIO kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Riok1 |
| Official Name | RIO kinase 1 [Source:RGD Symbol;Acc:1306086] |
| Ensembl ID | ENSRNOG00000014049 |
| Bio databases IDs | |
| Aliases | RIO kinase 1 |
| Synonyms | 3110046C13Rik, 5430416A05RIK, AD034, bA288G3.1, RIO1, RIO kinase 1, RRP10 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Riok1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- RIO1 family
- protein binding
- Rio2, N-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- organismal death
- hepatocellular carcinoma
- Kawasaki disease
- Shigella infection
role in cell
- phosphorylation in
- stabilization in
- signaling in
- crizotinib sensitivity
- serine phosphorylation in
- threonine phosphorylation in
- radioresistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pre-ribosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Riok1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maturation of SSU-rRNA
- ribosomal small subunit biogenesis
- positive regulation of rRNA processing
Cellular Component
Where in the cell the gene product is active
- methyltransferase complex
- cytosol
- preribosome, small subunit precursor
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- metal ion binding
- protein serine/threonine kinase activity
- hydrolase activity