IFIT3 Gene Summary [Human]
Enables identical protein binding activity. Involved in negative regulation of apoptotic process; negative regulation of cell population proliferation; and response to virus. Located in cytosol and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | IFIT3 |
| Official Name | interferon induced protein with tetratricopeptide repeats 3 [Source:HGNC Symbol;Acc:HGNC:5411] |
| Ensembl ID | ENSG00000119917 |
| Bio databases IDs | |
| Aliases | interferon induced protein with tetratricopeptide repeats 3 |
| Synonyms | CIG-41, CIG-49, GARG-49, IFI60, IFI-60K, IFIT4, interferon-induced protein with tetratricopeptide repeats 3, IRG2, ISG-561, ISG60, P60, RIG-G |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IFIT3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- identical protein binding
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the IFIT3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- dermatomyositis
- diffuse cutaneous systemic sclerosis
- plasma cell myeloma
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- T-cell non-Hodgkin disease
- mature T-cell neoplasia
- tuberculosis
- uterine leiomyoma
- leiomyomatosis
role in cell
- proliferation
- migration
- growth
- apoptosis
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IFIT3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- negative regulation of apoptotic process
- defense response to virus
- response to virus
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding