Cyp3a18 Gene Summary [Rat]
Enables testosterone 16-alpha-hydroxylase activity and testosterone 6-beta-hydroxylase activity. Predicted to be involved in oxidative demethylation and steroid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Orthologous to human CYP3A43 (cytochrome P450 family 3 subfamily A member 43). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cyp3a18 |
| Official Name | cytochrome P450, family 3, subfamily a, polypeptide 18 [Source:RGD Symbol;Acc:628709] |
| Ensembl ID | ENSRNOG00000000969 |
| Bio databases IDs | |
| Aliases | cytochrome P450, family 3, subfamily a, polypeptide 18 |
| Synonyms | Cyp3a18, Cyp3a57, Cyp3a59, cytochrome P450, family 3, subfamily a, polypeptide 18, cytochrome P450, family 3, subfamily a, polypeptide 25, cytochrome P450, family 3, subfamily a, polypeptide 57, cytochrome P450, family 3, subfamily a, polypeptide 59, EG622127 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cyp3a18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- testosterone 16-alpha-hydroxylase
- reduced flavin or flavoprotein:oxygen oxidoreductase
- testosterone 6 beta-hydroxylase
- retinoic acid 4-hydroxylase
- enzyme
- steroid hydroxylase
Pathways
Biological processes and signaling networks where the Cyp3a18 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- endoplasmic reticulum membrane