Setd4 Gene Summary [Mouse]
Enables histone H3K4 methyltransferase activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of inflammatory response; and regulation of cell proliferation in bone marrow. Predicted to be located in cytosol and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human SETD4 (SET domain containing 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Setd4 |
| Official Name | SET domain containing 4 [Source:MGI Symbol;Acc:MGI:2136890] |
| Ensembl ID | ENSMUSG00000022948 |
| Bio databases IDs | |
| Aliases | SET domain containing 4 |
| Synonyms | C21ORF18, C21orf27, LOC102556275, ORF21, Rda279, SET domain containing 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Setd4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone lysine N-methyltransferase activity (H4-K20 specific)
- histone lysine N-methyltransferase activity (H3-K4 specific)
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- enzyme
- protein binding
- Rubisco LSMT substrate-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Setd4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- inflammatory response
- positive regulation of inflammatory response
- peptidyl-lysine trimethylation
- peptidyl-lysine monomethylation
- positive regulation of tumor necrosis factor production
- regulation of cell proliferation in bone marrow
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of interleukin-6 production
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
Molecular Function
What the gene product does at the molecular level
- histone methyltransferase activity (H3-K4 specific)
- transcription coactivator activity
- histone methyltransferase activity (H3-K36 specific)
- histone methyltransferase activity (H4-K20 specific)