Wwp1 Gene Summary [Mouse]
Enables ubiquitin protein ligase activity. Involved in negative regulation of DNA-templated transcription; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in limb; limb mesenchyme; and spinal cord. Orthologous to human WWP1 (WW domain containing E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Wwp1 |
| Official Name | WW domain containing E3 ubiquitin protein ligase 1 [Source:MGI Symbol;Acc:MGI:1861728] |
| Ensembl ID | ENSMUSG00000041058 |
| Bio databases IDs | |
| Aliases | WW domain containing E3 ubiquitin protein ligase 1 |
| Synonyms | 8030445B08Rik, AIP5, hSDRP1, SDRP1, Tiul1, WW domain containing E3 ubiquitin protein ligase 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Wwp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- catalytic domain
- ubiquitin protein ligase activity
- Domain Homologous to E6-AP Carboxyl Terminus with
- enzyme
- protein binding
- WW domain
- xPPxY motif
- HECTc
- Domain with 2 conserved Trp (W) residues
- ubiquitin-protein transferase activity
- WW
- Protein kinase C conserved region 2 (CalB)
- C2 domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- survival
- organismal death
- metabolic syndrome X
- thyroid cancer
- pancreatic cancer
- spondylolisthesis
role in cell
- expression in
- differentiation
- degradation in
- number
- migration
- accumulation in
- entrance
- ubiquitination in
- transport in
- turnover in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell periphery
- cellular membrane
- Plasma Membrane
- cytosol
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Wwp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- proteasomal ubiquitin-dependent protein catabolic process
- central nervous system development
- negative regulation of transcription, DNA-dependent
- signal transduction
- ion transmembrane transport
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- ubiquitin ligase complex
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding