Usp11 Gene Summary [Mouse]
Predicted to enable cysteine-type deubiquitinase activity; cysteine-type endopeptidase activity; and transcription corepressor binding activity. Predicted to be involved in protein deubiquitination. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in brain; cortical plate; dorsal root ganglion; and spinal cord. Orthologous to human USP11 (ubiquitin specific peptidase 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp11 |
| Official Name | ubiquitin specific peptidase 11 [Source:MGI Symbol;Acc:MGI:2384312] |
| Ensembl ID | ENSMUSG00000031066 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 11 |
| Synonyms | 6230415D12Rik, mKIAA4085, ubiquitin specific peptidase 11, UHX1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin thiolesterase
- cysteine endopeptidase
- peptidase
- ubiquitin-specific protease
- DUSP domain
- transcription factor binding
- protein binding
- ubiquitin-like domain
Pathways
Biological processes and signaling networks where the Usp11 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- metastasis
- liver cancer
- prostate cancer
- spatial memory impairment
- microgliosis
- organismal death
- hepatocellular carcinoma
- T acute lymphoblastic leukemia
role in cell
- activation in
- accumulation
- apoptosis
- proliferation
- expression in
- accumulation in
- ubiquitination in
- cell viability
- phosphorylation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- chromosome
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- ubiquitin-specific protease activity
- protein binding
- cysteine-type endopeptidase activity