Impdh1 Gene Summary [Mouse]
Enables IMP dehydrogenase activity. Involved in 'de novo' XMP biosynthetic process and GMP biosynthetic process. Acts upstream of or within lymphocyte proliferation and purine nucleotide biosynthetic process. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Is expressed in central nervous system and retina outer nuclear layer. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Impdh1 |
| Official Name | inosine monophosphate dehydrogenase 1 [Source:MGI Symbol;Acc:MGI:96567] |
| Ensembl ID | ENSMUSG00000003500 |
| Bio databases IDs | |
| Aliases | inosine monophosphate dehydrogenase 1 |
| Synonyms | B930086D20Rik, IMPD, IMPD 1, IMPDH-I, inosine monophosphate dehydrogenase 1, LCA11, RP10, sWSS2608, Tcbp/imdh1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Impdh1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CBS_pair_SF
- Domain in cystathionine beta-synthase and other proteins
- IMP dehydrogenase
- nucleic acid binding
- TIM-like beta/alpha barrel domains
- CBS domain
- IMP dehydrogenase / GMP reductase domain
- enzyme
- protein binding
- identical protein binding
- inosine-5'-monophosphate dehydrogenase
- DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- type M3 acute myeloid leukemia
- anemia
- HIV infection
- lymphoma
- myelodysplastic syndrome
- plasma cell myeloma
- leukemia
- intermediate uveitis
- panuveitis
role in cell
- proliferation
- activation
- abnormal morphology
- function
- cytotoxicity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- azurophil granule lumen
- Extracellular Space
- Nucleus
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Impdh1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- GTP biosynthetic process
- GMP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
- secretory granule lumen
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- nucleic acid binding
- DNA binding
- RNA binding
- metal ion binding
- IMP dehydrogenase activity