Gpr4 Gene Summary [Mouse]
Enables G protein-coupled receptor activity. Involved in positive regulation of inflammatory response and regulation of vascular permeability. Acts upstream of or within several processes, including blood vessel development; negative regulation of angiogenesis; and response to acidic pH. Predicted to be active in plasma membrane. Is expressed in cerebral cortex. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gpr4 |
| Official Name | G protein-coupled receptor 4 [Source:MGI Symbol;Acc:MGI:2441992] |
| Ensembl ID | ENSMUSG00000044317 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 4 |
| Synonyms | GPR6C.l, G protein-coupled receptor 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gpr4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the Gpr4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver neoplasm
- liver neoplasia
- hypoplasia
- bleeding
- dextran sodium sulfate-induced colitis
- colitis
- breast carcinoma
- hypercapnia
- petechia
role in cell
- proliferation
- formation
- transformation
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gpr4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis involved in wound healing
- negative regulation of angiogenesis
- positive regulation of Rho protein signal transduction
- G-protein coupled receptor signaling pathway
- glomerular mesangial cell development
- positive regulation of inflammatory response
- regulation of vascular permeability
- response to acidity
- regulation of cell adhesion
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- phospholipase C-activating G-protein coupled receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity