GPR4

GPR4 Gene Summary

Enables G protein-coupled receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; and response to acidic pH. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
GPR4
Official Name
G protein-coupled receptor 4 [Source:HGNC Symbol;Acc:HGNC:4497]
Ensembl ID
ENSG00000177464
Bio databases IDs NCBI: 2828 Ensembl: ENSG00000177464
Aliases G protein-coupled receptor 4
Synonyms
GPR6C.l,G protein-coupled receptor 4
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • G-protein coupled receptor
  • Cholecystokinin A receptor, N-terminal
  • 7 transmembrane receptor (rhodopsin family)
  • seven-transmembrane G protein-coupled receptor superfamily

Pathways

Biological processes and signaling networks where the GPR4 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • neoplasia
  • liver neoplasm
  • liver neoplasia
  • hypoplasia
  • bleeding
  • dextran sodium sulfate-induced colitis
  • colitis
  • breast carcinoma
  • hypercapnia
  • petechia
regulated by
  • TP53
  • EGF
  • KRAS
  • PTEN
  • RB1
  • PIK3CA
  • VEGF
  • FGF8
  • HGF
  • sphingosylphosphocholine
regulates
  • cyclic AMP
  • creatinine
  • reporter gene
  • synthetic promoter
  • RHOA
  • VCAM1
  • ICAM1
role in cell
  • proliferation
  • formation
  • transformation
  • adhesion

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Plasma Membrane
  • cellular membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the GPR4 gene, providing context for its role in the cell.

BIOLOGICAL PROCESS

Functions and activities the gene product is involved in
  • angiogenesis involved in wound healing
  • negative regulation of angiogenesis
  • positive regulation of Rho protein signal transduction
  • G-protein coupled receptor signaling pathway
  • glomerular mesangial cell development
  • positive regulation of inflammatory response
  • regulation of vascular permeability
  • response to acidity
  • regulation of cell adhesion
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway
  • phospholipase C-activating G-protein coupled receptor signaling pathway

CELLULAR COMPONENT

Where in the cell the gene product is active
  • plasma membrane

MOLECULAR FUNCTION

What the gene product does at the molecular level
  • G-protein coupled receptor activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.