Fgf8 Gene Summary [Mouse]
Predicted to enable signaling receptor binding activity. Involved in outflow tract septum morphogenesis. Acts upstream of or within several processes, including brain development; circulatory system development; and embryonic morphogenesis. Predicted to be located in external side of plasma membrane. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including alimentary system; branchial arch; embryo ectoderm; embryo mesenchyme; and sensory organ. Used to study DiGeorge syndrome and tetralogy of Fallot. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 6 with or without anosmia and prostate carcinoma in situ. Orthologous to human FGF8 (fibroblast growth factor 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fgf8 |
| Official Name | fibroblast growth factor 8 [Source:MGI Symbol;Acc:MGI:99604] |
| Ensembl ID | ENSMUSG00000025219 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor 8 |
| Synonyms | AIGF, Fgf6c, fibroblast growth factor 8, HBGF-8, HH6, KAL6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fgf8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- beta-trefoil_FGF
- type 2 fibroblast growth factor receptor binding
- type 1 fibroblast growth factor receptor binding
- chemoattractant
- growth factor
Pathways
Biological processes and signaling networks where the Fgf8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- cancer
- hyperplasia
- neoplasia
- epithelial cancer
- epithelial neoplasia
- hypogonadotropic hypogonadism 6
- holoprosencephaly
- organismal death
- nasopharyngeal cancer
role in cell
- proliferation
- expression in
- apoptosis
- growth
- quantity
- activation in
- outgrowth
- cell death
- survival
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Plasma Membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fgf8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- neuroepithelial cell differentiation
- positive chemotaxis
- cell migration involved in mesendoderm migration
- thyroid-stimulating hormone-secreting cell differentiation
- signal transduction involved in regulation of gene expression
- forebrain dorsal/ventral pattern formation
- fibroblast growth factor receptor signaling pathway
- positive regulation of mitosis
- branching involved in salivary gland morphogenesis
- dorsal/ventral pattern formation
- corticotropin hormone secreting cell differentiation
- mesonephros development
- heart looping
- neuron apoptotic process
- embryonic hindlimb morphogenesis
- mesodermal cell migration
- neuron differentiation
- subpallium development
- positive regulation of organ growth
- response to organic cyclic compound
- pharyngeal system development
- organ morphogenesis
- pallium development
- aorta morphogenesis
- male genitalia development
- positive regulation of stem cell proliferation
- positive regulation of gene expression
- organ induction
- neural plate morphogenesis
- dorsal/ventral axon guidance
- regulation of cell migration
- organ growth
- motor axon guidance
- positive regulation of cell proliferation
- anatomical structure morphogenesis
- response to xenobiotic stimulus
- odontogenesis
- epithelial to mesenchymal transition involved in endocardial cushion formation
- forebrain morphogenesis
- negative regulation of neuron apoptotic process
- lung morphogenesis
- positive regulation of G-protein coupled receptor protein signaling pathway
- bone development
- outflow tract septum morphogenesis
- MAPK cascade
- response to oxidative stress
- positive regulation of cell division
- patterning of blood vessels
- stem cell proliferation
- negative regulation of cardiac muscle tissue development
- positive regulation of peptidyl-tyrosine phosphorylation
- cell proliferation in forebrain
- embryonic neurocranium morphogenesis
- midbrain-hindbrain boundary development
- positive regulation of cell differentiation
- positive regulation of MAPK cascade
- regulation of odontogenesis of dentin-containing tooth
- gastrulation
- forebrain neuron development
- gonad development
- thyroid gland development
- blood vessel remodeling
- metanephros development
- dopaminergic neuron differentiation
- branching involved in ureteric bud morphogenesis
- otic vesicle formation
- positive regulation of protein phosphorylation
- cell fate commitment
- positive regulation of ERK1 and ERK2 cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- external side of plasma membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- chemoattractant activity
- type 2 fibroblast growth factor receptor binding
- type 1 fibroblast growth factor receptor binding