Syt11 Gene Summary [Rat]
Predicted to enable several functions, including beta-tubulin binding activity; calcium ion sensor activity; and ubiquitin protein ligase binding activity. Involved in negative regulation of cellular component organization and negative regulation of dopamine secretion. Located in several cellular components, including inhibitory synapse; postsynaptic density; and synaptic vesicle. Is active in several cellular components, including Schaffer collateral - CA1 synapse; presynaptic active zone membrane; and synaptic vesicle membrane. Orthologous to human SYT11 (synaptotagmin 11). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syt11 |
| Official Name | synaptotagmin 11 [Source:RGD Symbol;Acc:62042] |
| Ensembl ID | ENSRNOG00000020279 |
| Bio databases IDs | |
| Aliases | synaptotagmin 11 |
| Synonyms | 1500004A13RIK, 3632445O20RIK, 5430404N14Rik, 6530420C11Rik, AI851970, BB132176, synaptotagmin 11, Synaptotagmin XI, SYT12, sytXI |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Syt11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SNARE binding
- beta-tubulin binding
- ubiquitin protein ligase binding
- cytoplasmic domain
- protein binding
- Protein kinase C conserved region 2 (CalB)
- identical protein binding
- transporter
- C2 domain
Pathways
Biological processes and signaling networks where the Syt11 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- gastric cancer
- metastasis
- diffuse gastric cancer
role in cell
- phosphorylation in
- expression in
- quantity
- growth
- autophagy by
- phagocytosis by
- maturation
- number
- endocytosis
- density
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic vesicle membrane
- presynaptic regions
- perinuclear region
- postsynaptic region
- cellular membrane
- Plasma Membrane
- vesicles
- lysosome
- presynaptic membrane
- trans Golgi network
- dendritic spines
- synaptic vesicles
- neurites
- synapse
- recycling endosomes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- excitatory synapses
- phagosomes
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Syt11 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endocytosis
- negative regulation of neurotransmitter secretion
- regulation of synaptic vesicle endocytosis
- learning
- memory
- regulation of defense response to bacterium
- negative regulation of interleukin-6 production
- calcium ion-dependent exocytosis of neurotransmitter
- plasma membrane repair
- vesicle fusion
- establishment of vesicle localization
- autophagy
- negative regulation of cytokine production
- negative regulation of dopamine secretion
- negative regulation of tumor necrosis factor production
- negative regulation of phagocytosis
Cellular Component
Where in the cell the gene product is active
- inhibitory synapse
- postsynaptic density
- synaptic vesicle
- excitatory synapse
- phagocytic vesicle
- synapse
- presynaptic active zone membrane
- perikaryon
- phagocytic cup
- neuron projection
- lysosomal membrane
- plasma membrane
- lysosome
- exocytic vesicle
- dendrite
- early phagosome
- trans-Golgi network
- dendritic spine
- vesicle
- recycling endosome
- recycling endosome membrane
- axon
- clathrin coated vesicle membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- identical protein binding
- ubiquitin protein ligase binding
- protein binding
- beta-tubulin binding
- calcium ion binding
- SNARE binding
- clathrin binding
- translation initiation factor binding
- calcium-dependent phospholipid binding