SYT11 Gene Summary [Human]

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that are known calcium sensors and mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. The encoded protein is also a substrate for ubiquitin-E3-ligase parkin. The gene has previously been referred to as synaptotagmin XII but has been renamed synaptotagmin XI to be consistent with mouse and rat official nomenclature. [provided by RefSeq, Apr 2010]

Details

Type
Protein Coding
Official Symbol
SYT11
Official Name
synaptotagmin 11 [Source:HGNC Symbol;Acc:HGNC:19239]
Ensembl ID
ENSG00000132718
Bio databases IDs NCBI: 23208 Ensembl: ENSG00000132718
Aliases synaptotagmin 11
Synonyms 1500004A13RIK, 3632445O20RIK, 5430404N14Rik, 6530420C11Rik, AI851970, BB132176, synaptotagmin 11, Synaptotagmin XI, SYT12, sytXI
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SYT11 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • SNARE binding
  • beta-tubulin binding
  • ubiquitin protein ligase binding
  • cytoplasmic domain
  • protein binding
  • Protein kinase C conserved region 2 (CalB)
  • identical protein binding
  • transporter
  • C2 domain

Pathways

Biological processes and signaling networks where the SYT11 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • gastric cancer
  • metastasis
  • diffuse gastric cancer
regulated by
  • testosterone
  • beta-estradiol
  • TNF
  • IL4
  • GP63
  • STAT6
  • RAW 264.7 cells
  • lactic acid
  • ERN1
  • lipophosphonoglycan
regulates
role in cell
  • phosphorylation in
  • expression in
  • quantity
  • growth
  • autophagy by
  • phagocytosis by
  • maturation
  • number
  • endocytosis
  • density

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • synaptic vesicle membrane
  • presynaptic regions
  • perinuclear region
  • postsynaptic region
  • cellular membrane
  • Plasma Membrane
  • vesicles
  • lysosome
  • presynaptic membrane
  • trans Golgi network
  • dendritic spines
  • synaptic vesicles
  • neurites
  • synapse
  • recycling endosomes
  • perikaryon
  • axons
  • dendrites
  • postsynaptic density
  • axon terminals
  • excitatory synapses
  • phagosomes
  • phagocytic cups

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human SYT11 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of endocytosis
  • negative regulation of neurotransmitter secretion
  • regulation of synaptic vesicle endocytosis
  • learning
  • memory
  • regulation of defense response to bacterium
  • negative regulation of interleukin-6 production
  • calcium ion-dependent exocytosis of neurotransmitter
  • plasma membrane repair
  • vesicle fusion
  • establishment of vesicle localization
  • autophagy
  • negative regulation of cytokine production
  • negative regulation of dopamine secretion
  • negative regulation of tumor necrosis factor production
  • negative regulation of phagocytosis

Cellular Component

Where in the cell the gene product is active
  • inhibitory synapse
  • postsynaptic density
  • synaptic vesicle
  • excitatory synapse
  • phagocytic vesicle
  • synapse
  • presynaptic active zone membrane
  • perikaryon
  • phagocytic cup
  • neuron projection
  • lysosomal membrane
  • plasma membrane
  • lysosome
  • exocytic vesicle
  • dendrite
  • early phagosome
  • trans-Golgi network
  • dendritic spine
  • vesicle
  • recycling endosome
  • recycling endosome membrane
  • axon
  • clathrin coated vesicle membrane

Molecular Function

What the gene product does at the molecular level
  • phosphatidylserine binding
  • identical protein binding
  • ubiquitin protein ligase binding
  • protein binding
  • beta-tubulin binding
  • calcium ion binding
  • SNARE binding
  • clathrin binding
  • translation initiation factor binding
  • calcium-dependent phospholipid binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.