Sgta Gene Summary [Rat]
Enables identical protein binding activity. Involved in chaperone-mediated protein folding; protein heterooligomerization; and protein homooligomerization. Is active in presynapse. Is extrinsic component of synaptic vesicle membrane. Orthologous to human SGTA (small glutamine rich tetratricopeptide repeat co-chaperone alpha). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sgta |
| Official Name | small glutamine rich tetratricopeptide repeat containing alpha [Source:RGD Symbol;Acc:620815] |
| Ensembl ID | ENSRNOG00000019891 |
| Bio databases IDs | |
| Aliases | small glutamine rich tetratricopeptide repeat containing alpha |
| Synonyms | 5330427H01Rik, alphaSGT, D10Ertd190e, hSGT, SGT, SGT1, small glutamine rich tetratricopeptide repeat co-chaperone alpha, small glutamine rich tetratricopeptide repeat co-chaperone α, small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha, small glutamine-rich tetratricopeptide repeat (TPR)-containing, α, Stg, Vpu, Vpu-binding |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Sgta often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TPR repeat
- binding protein
- Tetratricopeptide repeats
- Homodimerization domain of SGTA
- protein homodimerization
- protein binding
- tetratricopeptide repeat
- identical protein binding
- protein heterodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosolic synaptosomal fraction
- presynaptic regions
- cellular membrane
- Nucleus
- vesicles
- cytosol
- nucleoplasm
- synaptic vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Sgta gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
- tail-anchored membrane protein insertion into ER membrane
- posttranslational protein targeting to membrane
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- membrane
- cytosol
- TRC complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- binding, bridging