Syncrip Gene Summary [Rat]
Enables mRNA 3'-UTR binding activity and mRNA 5'-UTR binding activity. Involved in circadian rhythm; negative regulation of mRNA modification; and positive regulation of translation. Located in neuronal cell body and proximal dendrite. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human SYNCRIP (synaptotagmin binding cytoplasmic RNA interacting protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syncrip |
| Official Name | synaptotagmin binding, cytoplasmic RNA interacting protein [Source:RGD Symbol;Acc:1305683] |
| Ensembl ID | ENSRNOG00000000204 |
| Bio databases IDs | |
| Aliases | synaptotagmin binding, cytoplasmic RNA interacting protein |
| Synonyms | 2610109K23Rik, 4632417O19Rik, Ab2-339, GRY-RBP, HNRNPQ, HNRPQ, HNRPQ1, LOC100910033, NS1-associated protein 1, NSAP1, Nsap1l, PP68, synaptotagmin binding cytoplasmic RNA interacting protein, synaptotagmin binding, cytoplasmic RNA interacting protein |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Syncrip often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ELAV/HuD family splicing factor
- RGG domain
- RNA recognition motif (RRM) superfamily
- mRNA 3' UTR binding
- mRNA 5' UTR binding
- RNA recognition motif
- Heterogeneous nuclear ribonucleoprotein Q acidic domain
- poly(A) binding protein
- protein binding
- heterogeneous nuclear ribonucleoprotein R, Q family
- NURR (N-terminal unit for RNA recognition) domain
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- adult T-cell leukemia/lymphoma
- mature T-cell neoplasia
- T-cell non-Hodgkin disease
- psoriasis
- pervasive developmental disorder
- tumorigenesis
- preeclampsia
- plexiform neurofibroma
role in cell
- growth
- production in
- expression in
- migration
- apoptosis
- phosphorylation in
- repression in
- quantity
- mesenchymal epithelial transition
- morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- microsomal fraction
- nuclear fraction
- detergent-insoluble fractions
- polyribosome fractions
- glutaminergic synapse
- endoplasmic reticulum mitochondria contact site
- catalytic step 2 spliceosome
- Cytoplasm
- cell surface
- ribosome
- polysomes
- cytosol
- spliceosomes
- nucleoplasm
- dendrite initial segments
- perikaryon
- postsynaptic density
- clathrin-coated vesicles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Syncrip gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- positive regulation of cytoplasmic translation
- negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
- osteoblast differentiation
- RNA processing
- cellular response to interferon-gamma
- CRD-mediated mRNA stabilization
- negative regulation of translation
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- CRD-mediated mRNA stability complex
- nucleus
- catalytic step 2 spliceosome
- membrane
- histone pre-mRNA 3'end processing complex
- cytosol
- endoplasmic reticulum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA 5'-UTR binding