Il4 Gene Summary [Rat]
Predicted to enable cytokine activity. Involved in several processes, including positive regulation of leukocyte migration; regulation of biosynthetic process; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; rhinitis (multiple); and trypanosomiasis. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il4 |
| Official Name | interleukin 4 [Source:RGD Symbol;Acc:2898] |
| Ensembl ID | ENSRNOG00000007624 |
| Bio databases IDs | |
| Aliases | interleukin 4 |
| Synonyms | BCGF, BCGF-1, BSF-1, Il4e12, interleukin 4 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- interleukin-4 receptor binding
- Interleukin 4
- protein binding
- cytokine
Pathways
Biological processes and signaling networks where the Il4 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Airway Inflammation in Asthma
- Allograft Rejection Signaling
- Autoimmune Thyroid Disease Signaling
- Communication between Innate and Adaptive Immune Cells
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Erythropoietin Signaling
- Fc Epsilon RI Signaling
- Glucocorticoid Receptor Signaling
- Hematopoiesis from Multipotent Stem Cells
- Hematopoiesis from Pluripotent Stem Cells
- Hepatic Cholestasis
- Hepatic Fibrosis / Hepatic Stellate Cell Activation
- HMGB1 Signaling
- IL-17 Signaling
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of JAK1 and JAK3 in γc Cytokine Signaling
- Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- T Helper Cell Differentiation
- Th1 Pathway
- Th2 Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- fibrosis
- cancer
- hepatitis
- allergic asthma
- neoplasia
- COVID-19
- metastasis
- infection
- systemic lupus erythematosus
- sepsis
role in cell
- growth
- quantity
- morphology
- accumulation in
- transformation
- development
- cell death
- synthesis in
- expression in
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- Nucleus
- plasma membrane extracellular face
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- activation of Janus kinase activity
- positive regulation of ATP biosynthetic process
- positive regulation of cell proliferation
- T cell activation
- cholesterol metabolic process
- positive regulation of tyrosine phosphorylation of STAT protein
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of MHC class II biosynthetic process
- macrophage activation
- negative regulation of transcription from RNA polymerase II promoter
- immune response
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- myeloid dendritic cell differentiation
- negative regulation of osteoclast differentiation
- dendritic cell differentiation
- negative regulation of epithelial cell migration
- negative regulation of endothelial cell apoptotic process
- regulation of isotype switching
- positive regulation of receptor-mediated endocytosis
- negative regulation of tumor necrosis factor production
- regulation of immune response
- positive regulation of T-helper 2 cell cytokine production
- positive regulation of macroautophagy
- interleukin-4-mediated signaling pathway
- B cell differentiation
- negative regulation of inflammatory response
- positive regulation of beta-amyloid clearance
- positive regulation of isotype switching to IgG isotypes
- positive regulation of T cell proliferation
- regulation of phosphorylation
- type 2 immune response
- positive regulation of interleukin-13 production
- positive regulation of isotype switching to IgE isotypes
- negative regulation of apoptotic process
- positive regulation of T cell differentiation
- positive regulation of gene expression
- positive regulation of B cell proliferation
- positive regulation of interleukin-10 production
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular region
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- interleukin-4 receptor binding