Il6 Gene Summary [Rat]
Enables cytokine activity and interleukin-6 receptor binding activity. Involved in several processes, including cellular response to cytokine stimulus; positive regulation of cell communication; and positive regulation of metabolic process. Located in extracellular space. Used to study several diseases, including acute necrotizing pancreatitis; disseminated intravascular coagulation; hypertension (multiple); impotence; and steatotic liver disease. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); auditory system disease (multiple); gastrointestinal system cancer (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); glucose metabolism disease (multiple); and periodontal disease (multiple). Orthologous to human IL6 (interleukin 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Il6 |
| Official Name | interleukin 6 [Source:RGD Symbol;Acc:2901] |
| Ensembl ID | ENSRNOG00000010278 |
| Bio databases IDs | |
| Aliases | interleukin 6 |
| Synonyms | BSF-2, CDF, FDGI, HGF, HSF, IFNB2, IFN-beta-2, IFN beta 2A, IFN-β-2, IFN β 2A, ILg6, interleukin-6 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Il6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- receptor binding domain
- AB loop
- CD loop
- interleukin-6 receptor binding
- Interleukin-6/G-CSF/MGF family
- protein binding
- receptor binding
- cytokine
- identical protein binding
- gp130 binding domain
- growth factor
- D helix
Pathways
Biological processes and signaling networks where the Il6 gene in rat plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Airway Pathology in Chronic Obstructive Pulmonary Disease
- Apelin Cardiac Fibroblast Signaling Pathway
- Aryl Hydrocarbon Receptor Signaling
- Atherosclerosis Signaling
- Crosstalk between Dendritic Cells and Natural Killer Cells
- Differential Regulation of Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F
- Erythropoietin Signaling
- Glucocorticoid Receptor Signaling
- Hematopoiesis from Pluripotent Stem Cells
- HGF Signaling
- IL-15 Production
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Fibroblasts
- IL-6 Signaling
- JAK/Stat Signaling
- LXR/RXR Activation
- PPARα/RXRα Activation
- Role of Cytokines in Mediating Communication between Immune Cells
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- SPINK1 General Cancer Pathway
- T Helper Cell Differentiation
- TREM1 Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- chronic kidney disease
- diabetes mellitus
- cardiovascular disorder
- chronic lymphocytic leukemia
- neoplasia
- metastasis
- hepatitis
- heart failure
- coronary disease
role in cell
- quantity
- growth
- proliferation
- generation in
- migration
- cell viability
- expression in
- accumulation in
- sphere formation
- apoptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- intracellular space
- cellular membrane
- Nucleus
- Plasma Membrane
- vesicles
- endoplasmic reticulum lumen
- plasma membrane extracellular face
- specific granules
- secretory granules
- exosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Il6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- response to peptidoglycan
- regulation of angiogenesis
- positive regulation of tyrosine phosphorylation of STAT protein
- regulation of glucagon secretion
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of cytokine production involved in inflammatory response
- glucagon secretion
- positive regulation of acute inflammatory response
- regulation of insulin secretion
- germinal center B cell differentiation
- inflammatory response
- negative regulation of collagen biosynthetic process
- positive regulation of B cell activation
- negative regulation of primary miRNA processing
- positive regulation of transcription, DNA-dependent
- humoral immune response
- T-helper 17 cell lineage commitment
- positive regulation of immunoglobulin production
- positive regulation of type B pancreatic cell apoptotic process
- defense response to virus
- positive regulation of tumor necrosis factor production
- regulation of vascular endothelial growth factor production
- positive regulation of chemokine production
- vascular endothelial growth factor production
- maintenance of blood-brain barrier
- defense response to Gram-positive bacterium
- positive regulation of T-helper 2 cell cytokine production
- positive regulation vascular endothelial growth factor production
- positive regulation of peptidyl-serine phosphorylation
- negative regulation of chemokine production
- positive regulation of leukocyte chemotaxis
- positive regulation of T cell proliferation
- negative regulation of bone resorption
- positive regulation of JAK-STAT cascade
- positive regulation of interleukin-8 production
- neutrophil mediated immunity
- hepatocyte proliferation
- positive regulation of gene expression
- glucose homeostasis
- negative regulation of neurogenesis
- response to activity
- positive regulation of interleukin-6 production
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- hepatic immune response
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of osteoblast differentiation
- positive regulation of smooth muscle cell proliferation
- positive regulation of epithelial to mesenchymal transition
- cytokine-mediated signaling pathway
- response to glucocorticoid stimulus
- positive regulation of interleukin-17 production
- interleukin-6-mediated signaling pathway
- cellular response to hydrogen peroxide
- endocrine pancreas development
- positive regulation of interleukin-21 production
- platelet activation
- positive regulation of peptidyl-tyrosine phosphorylation
- defense response to Gram-negative bacterium
- neuron projection development
- positive regulation of glial cell proliferation
- negative regulation of fat cell differentiation
- positive regulation of MAPK cascade
- acute-phase response
- neutrophil apoptotic process
- positive regulation of extracellular matrix disassembly
- neuron homeostasis
- cellular response to lipopolysaccharide
- monocyte chemotaxis
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- negative regulation of lipid storage
- negative regulation of interleukin-1-mediated signaling pathway
- positive regulation of interleukin-10 production
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- extracellular region
- interleukin-6 receptor complex
Molecular Function
What the gene product does at the molecular level
- growth factor activity
- protein binding
- cytokine activity
- interleukin-6 receptor binding