Panx2 Gene Summary [Rat]
Enables gap junction channel activity. Involved in cell-cell signaling. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Orthologous to human PANX2 (pannexin 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Panx2 |
| Official Name | pannexin 2 [Source:RGD Symbol;Acc:735191] |
| Ensembl ID | ENSRNOG00000055530 |
| Bio databases IDs | |
| Aliases | pannexin 2 |
| Synonyms | hPANX2, pannexin 2, PX2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Panx2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- structural molecule
- transporter
- gap-junction forming channel
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cellular membrane
- perikaryon
- Herring bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Panx2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cation transport
- response to ischemia
- ion transmembrane transport
- cell-cell signaling
- positive regulation of interleukin-1 production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- wide pore channel activity
- gap junction hemi-channel activity
- structural molecule activity