Cldn7 Gene Summary [Rat]
Enables cell adhesion molecule binding activity and protein domain specific binding activity. Involved in several processes, including negative regulation of protein-containing complex assembly; positive regulation of cell motility; and response to ethanol. Located in basolateral plasma membrane and lateral plasma membrane. Orthologous to human CLDN7 (claudin 7). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cldn7 |
| Official Name | claudin 7 [Source:RGD Symbol;Acc:68432] |
| Ensembl ID | ENSRNOG00000017325 |
| Bio databases IDs | |
| Aliases | claudin 7 |
| Synonyms | CEPTRL2, claudin-1, claudin 7, cld-7, CPETRL2, Hs.84359 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Cldn7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cell adhesion molecule binding
- PMP-22/EMP/MP20/Claudin family
- extracellular loop
- protein domain specific binding
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the Cldn7 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- psoriasis
- organismal death
- serous ovarian adenocarcinoma
- serous ovarian cancer
- mucinous ovarian carcinoma
- mucinous ovarian cancer
- growth failure
- gastric cancer
- ovarian cancer
role in cell
- expression in
- binding in
- activation in
- proliferation
- migration
- apoptosis
- adhesion
- invasion
- invasiveness
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- apicolateral membrane
- cell junction
- cell surface
- cell borders
- cellular membrane
- cell-cell contacts
- basolateral membrane
- lateral plasma membrane
- endolysosomes
- tight junctions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Cldn7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- calcium-independent cell-cell adhesion
- response to ethanol
- negative regulation of cell adhesion
- negative regulation of apoptotic process
- positive regulation of cell proliferation
- tight junction assembly
- negative regulation of protein complex assembly
- cell adhesion
- positive regulation of cell motility
Cellular Component
Where in the cell the gene product is active
- apicolateral plasma membrane
- tight junction
- lateral plasma membrane
- basolateral plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein domain specific binding
- protein binding
- cell adhesion molecule binding
- structural molecule activity