Panx1 Gene Summary [Rat]
The protein encoded by this gene is a plasma membrane protein that is a structural component of gap junctions. The encoded protein acts as a homodimer or as a heterodimer with other isoforms or proteins. Two additional variants have been found, and the isoforms expressed from them are found in the cytoplasm. It is thought that these two isoforms could attenuate the actions of the membrane-bound protein. [provided by RefSeq, Jul 2012]
Details
| Type | Protein Coding |
| Official Symbol | Panx1 |
| Official Name | Pannexin 1 [Source:RGD Symbol;Acc:735204] |
| Ensembl ID | ENSRNOG00000010060 |
| Bio databases IDs | |
| Aliases | Pannexin 1 |
| Synonyms | MRS1, OOMD7, OZEMA7, PANNEXIN 1, PX1, UNQ2529 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Panx1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protease binding
- calcium channel
- channel/pore class transporter
- protein binding
- receptor binding
- identical protein binding
- gap-junction forming channel
- actin filament binding
- ATP transporter
- anion channel
- binding protein
- actin binding
- ion channel binding
- structural molecule
- transporter
Pathways
Biological processes and signaling networks where the Panx1 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Parkinson disease
- liver disease
- experimental autoimmune encephalomyelitis
- atopic dermatitis
- motor dysfunction
- neurological deficiency
- oocyte maturation defect type 7
- organismal death
- hypothyroidism
role in cell
- cellular infiltration by
- proliferation
- phosphorylation in
- number
- expression in
- development
- differentiation
- apoptosis
- cell death
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum-plasma membrane junction
- Cytoplasm
- intracellular space
- cellular membrane
- Endoplasmic Reticulum
- plasma membrane projections
- sarcolemma
- gap junctions
- membrane processes
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Panx1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of macrophage cytokine production
- response to ischemia
- cation transport
- response to ATP
- oogenesis
- calcium ion transport
- cell-cell signaling
- calcium ion transmembrane transport
- positive regulation of interleukin-1 alpha production
- ATP transport
- positive regulation of interleukin-1 beta production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- gap junction
- membrane
- bleb
- macromolecular complex
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- wide pore channel activity
- calcium channel activity
- gap junction hemi-channel activity
- structural molecule activity
- anion channel activity
- protease binding
- receptor binding
- ion channel binding
- leak channel activity
- ATP transmembrane transporter activity
- actin filament binding
- scaffold protein binding
- protein binding