Soat1 Gene Summary [Rat]
Enables sterol O-acyltransferase activity. Predicted to be involved in several processes, including cholesterol efflux; cholesterol homeostasis; and macrophage derived foam cell differentiation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human SOAT1 (sterol O-acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Soat1 |
| Official Name | sterol O-acyltransferase 1 [Source:RGD Symbol;Acc:621641] |
| Ensembl ID | ENSRNOG00000004111 |
| Bio databases IDs | |
| Aliases | sterol O-acyltransferase 1 |
| Synonyms | 8430426K15RIK, ACACT, ACAT, ACAT-1, Acyl-Coenzyme A Cholesterol Acyltransferase, ald, AW550831, hid, SOAT, STAT, sterol O-acyltransferase 1 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Soat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- sterol O-acyltransferase
- cholesterol binding
- acyl-CoA binding
- MBOAT, membrane-bound O-acyltransferase family
- enzyme
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cutaneous melanoma
- acute myeloid leukemia
- diffuse large B-cell lymphoma
- non-insulin-dependent diabetes mellitus
- atherosclerosis
- cardiovascular disorder
- disorder of coronary artery
- diabetes mellitus
- schizophrenia
- fibrosis
role in cell
- apoptosis
- expression in
- cell death
- proliferation
- phosphorylation in
- cell viability
- quantity
- differentiation
- formation
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- perinuclear region
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
- nuclear envelope
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Soat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- low-density lipoprotein particle clearance
- cholesterol storage
- cholesterol metabolic process
- very-low-density lipoprotein particle assembly
- macrophage derived foam cell differentiation
- cholesterol efflux
- cholesterol homeostasis
- positive regulation of amyloid precursor protein biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- protein binding
- cholesterol binding
- fatty-acyl-CoA binding
- cholesterol O-acyltransferase activity
- sterol O-acyltransferase activity