MUC17 Gene Summary [Human]
The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | MUC17 |
| Official Name | mucin 17, cell surface associated [Source:HGNC Symbol;Acc:HGNC:16800] |
| Ensembl ID | ENSG00000169876 |
| Bio databases IDs | |
| Aliases | mucin 17, cell surface associated |
| Synonyms | LOC100504874, MUC-3, Muc3a, mucin 17, cell surface associated |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MUC17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Family of unknown function (DUF5585)
- SEA domain
- protein binding
- PDZ-domain binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Golgi lumen
- plasma membrane extracellular face
- apical membrane
- microvilli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MUC17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular homeostasis
Cellular Component
Where in the cell the gene product is active
- external side of plasma membrane
- extracellular region
- Golgi lumen
- apical plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- PDZ domain binding
- extracellular matrix constituent, lubricant activity